1,2:5,6-二去水半乳糖醇（NSC-132313）的药理及抗肿瘤作用 - Suppr

Suppr

超能文献

Pharmacologic and antitumor effects of 1,2:5,6-dianhydrogalactitol (NSC-132313).

作者信息

Németh L, Institóris L, Somfai S, Gál F, Pályi I, Sugár J, Csuka O, Szentirmay Z, Kellner B

出版信息

Cancer Chemother Rep. 1972 Oct;56(5):593-602.

PMID:4652589

Abstract

摘要

相似文献

Pharmacologic and antitumor effects of 1,2:5,6-dianhydrogalactitol (NSC-132313).1,2:5,6-二去水半乳糖醇（NSC-132313）的药理及抗肿瘤作用

Cancer Chemother Rep. 1972 Oct;56(5):593-602.

The effect of cytostatic hexitol derivatives on haematopoietic stem cells, the L1210 leukaemia and C22LR osteosarcoma.细胞生长抑制剂己糖醇衍生物对造血干细胞、L1210白血病和C22LR骨肉瘤的作用。

Eur J Cancer (1965). 1975 Mar;11(3):169-73. doi: 10.1016/0014-2964(75)90112-7.

1,6-Di-O-methanesulphonyl-2,3-4,5-dianhydro-L-iditol, a new potential antitumour agent. Biological investigations.

Arzneimittelforschung. 1973 Jul;23(7):961-7.

Survival and phase sensitivity of HeLa cells treated with dianhydrogalactitol (NSC-132313).二去水半乳糖醇（NSC-132313）处理的HeLa细胞的存活及阶段敏感性

Cancer Chemother Rep. 1975 May-Jun;59(3):493-9.

Cell killing, kinetics, and recovery responses induced by 1,2:5,6-dianhydrogalactitol in dividing and nondividiing cells in vitro.1,2:5,6-二脱水半乳糖醇在体外对分裂细胞和非分裂细胞诱导的细胞杀伤、动力学及恢复反应。

J Natl Cancer Inst. 1977 Mar;58(3):657-63. doi: 10.1093/jnci/58.3.657.

Acute effect of endogenous inhibitors and exogenous cytostatics on the ultrastructure of bone marrow cells. I. Single dose of 1,2 : 5,6-dianhydrogalactitol (DAD).内源性抑制剂和外源性细胞抑制剂对骨髓细胞超微结构的急性影响。I. 单剂量1,2 : 5,6 - 二脱水半乳糖醇（DAD）

Haematologia (Budap). 1976;10(3-4):433-44.

Phase I evaluation of dianhydrogalactitol (NSC-132313).双脱水半乳糖醇（NSC - 132313）的I期评估

Cancer Treat Rep. 1976 May;60(5):611-4.

Phase II study of VP-16-213 versus dianhydrogalactitol in patients with metastatic malignant melanoma.VP-16-213与双去水半乳糖醇治疗转移性恶性黑色素瘤患者的II期研究。

Cancer Treat Rep. 1976 Nov;60(11):1681-2.

Biochemical rationales for the selection of combinations of chemotherapeutic agents.

Cancer Chemother Rep 2. 1974 Mar;4(1):131-6.

The effect of dibromodulcitol (NSC 104800) on intravenously induced cytemia of rats.二溴卫矛醇（NSC 104800）对大鼠静脉注射诱导的血细胞增多症的影响。

Neoplasma. 1971;18(5):533-7.

引用本文的文献

Updates in IDH-Wildtype Glioblastoma.IDH 野生型胶质母细胞瘤的最新进展。

Neurotherapeutics. 2022 Oct;19(6):1705-1723. doi: 10.1007/s13311-022-01251-6. Epub 2022 May 31.

Dianhydrogalactitol Overcomes Multiple Temozolomide Resistance Mechanisms in Glioblastoma.二聚失水卫矛醇克服胶质母细胞瘤中多种替莫唑胺耐药机制。

Mol Cancer Ther. 2021 Jun;20(6):1029-1038. doi: 10.1158/1535-7163.MCT-20-0319. Epub 2021 Apr 12.

Dianhydrogalactitol induces replication-dependent DNA damage in tumor cells preferentially resolved by homologous recombination.二羟甘露醇诱导肿瘤细胞中依赖复制的 DNA 损伤，这些损伤可被同源重组优先修复。

Cell Death Dis. 2018 Oct 3;9(10):1016. doi: 10.1038/s41419-018-1069-9.

Alkylation by 1,2:5,6-dianhydrogalactitol of deoxyribonucleic acid and guanosine.1,2:5,6-二脱水半乳糖醇对脱氧核糖核酸和鸟苷的烷基化作用。

Biochem J. 1980 Mar 1;185(3):659-66. doi: 10.1042/bj1850659.

Effect of a single high dose and repeated small doses of dianhydrogalactitol (DAG; NSC-132313) on rat intestinal mucosa.单次高剂量和重复小剂量双去水半乳糖醇（DAG；NSC-132313）对大鼠肠黏膜的影响。

Cancer Chemother Pharmacol. 1983;11(3):167-71. doi: 10.1007/BF00254198.

The role of comparative pharmacokinetics in the planning of human dose escalation: the experience with diacetyldianhydrogalactitol.比较药代动力学在人体剂量递增计划中的作用：双乙酰双去水半乳糖醇的经验

Cancer Chemother Pharmacol. 1988;22(2):109-13. doi: 10.1007/BF00257306.

Dominance of resistance to the alkylating agent 1,2:5,6-dianhydrogalactitol in P388 mouse lymphoma hybrid cells.

Cancer Chemother Pharmacol. 1989;23(1):41-6. doi: 10.1007/BF00258456.

Absence of cross-resistance between two alkylating agents: BCNU vs bifunctional galactitol.两种烷化剂之间不存在交叉耐药性：卡莫司汀与双功能半乳糖醇。

Cancer Chemother Pharmacol. 1989;24(5):311-3. doi: 10.1007/BF00304764.

New cancer chemotherapy drugs in Europe.

Cancer Chemother Pharmacol. 1978;1(1):5-13. doi: 10.1007/BF00253141.

New drugs under clinical evaluation in the United States.美国正在进行临床评估的新药。

Cancer Chemother Pharmacol. 1978;1(1):15-24. doi: 10.1007/BF00253142.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验