Kamrani Farzam, Mohammadzadeh Maryam, Sobhani Seyyed Reza, Khorasanchi Zahra
Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Sci Rep. 2025 May 9;15(1):16147. doi: 10.1038/s41598-025-98430-0.
The Phase Angle (PhA) and water cell distribution ratios are essential indicators of inflammation linked to serum inflammatory markers. We aim to investigate the relationship between PhA and extracellular water to total body water (ECW/TBW) ratio with hematological inflammatory markers. The study utilized data from the PERSIAN Organizational Cohort Study in Mashhad (POCM), incorporating information from bioelectrical impedance analysis (BIA) and blood tests. It examined two groups: individuals of normal weight (N = 1654) and those categorized as overweight or obese (N = 3651). In addition to Hemoglobin (Hgb), hematocrit (Hct), Platelet (Plt), White blood cell (WBC) and its components, the study also computed various hematologic inflammatory markers, such as platelet to HDL ratio (PHR), platelet to lymphocyte ratio (PLR), monocyte to HDL ratio (MHR), lymphocyte to HDL ratio (LHR), RDW to lymphocyte ratio (RLR), RDW to platelet ratio (RPR), and granulocyte to lymphocyte ratio (GLR). In the adjusted model, an increase in PhA is linked to increases in Hgb (Normal-weight: 17.1%, BMI > 25: 12.3%) and Hct (Normal-weight: 15.3%, BMI > 25: 13.6%), WBC (Normal-weight: 9%, BMI > 25: 6.8%), and RPR (Normal-weight: 17.1%, BMI > 25: 12.3%). Additionally, in the BMI > 25 categories, an increase in PhA is associated with increases in Plt (16.7%), Lymphocytes (5.6%), and PHR (5.2%). Furthermore, there is a decrease in RPR (Normal-weight: 7.4%, BMI > 25: 6.6%) with a unit increase in PhA. A unit increase in ECW/TBW is associated with a decrease in Hgb (Normal-weight: 19.9%, BMI > 25: 17.3%) and Hct (Normal-weight: 17.8%, BMI > 25: 17.6%). This is also linked to decreased WBC (9.6%) in the normal-weight category. Furthermore, in the BMI > 25 category, there are decreases in Plt (5.5%), RLR (6.5%), RPR (6.9%), GLR (5.9%), Granulocytes (7.5%), and Lymphocytes (8.3%) with an increase in ECW/TBW. The findings revealed that ECW/TBW demonstrates a stronger correlation with hematological markers than PhA, with these associations being particularly significant among normal-weight individuals. These results highlight the need for further research to explore the underlying mechanisms driving these relationships.
相角（PhA）和水细胞分布比率是与血清炎症标志物相关的炎症的重要指标。我们旨在研究PhA和细胞外水与总体水（ECW/TBW）比率与血液学炎症标志物之间的关系。该研究利用了来自马什哈德的波斯组织队列研究（POCM）的数据，纳入了生物电阻抗分析（BIA）和血液检测的信息。它考察了两组：正常体重个体（N = 1654）和超重或肥胖个体（N = 3651）。除了血红蛋白（Hgb）、血细胞比容（Hct）、血小板（Plt）、白细胞（WBC）及其组分外，该研究还计算了各种血液学炎症标志物，如血小板与高密度脂蛋白比率（PHR）、血小板与淋巴细胞比率（PLR）、单核细胞与高密度脂蛋白比率（MHR）、淋巴细胞与高密度脂蛋白比率（LHR）、红细胞分布宽度（RDW）与淋巴细胞比率（RLR）、RDW与血小板比率（RPR）以及粒细胞与淋巴细胞比率（GLR）。在调整模型中，PhA的增加与Hgb（正常体重组：17.1%，BMI>25组：12.3%）、Hct（正常体重组：15.3%，BMI>25组：13.6%）、WBC（正常体重组：9%，BMI>25组：6.8%）和RPR（正常体重组：17.1%，BMI>25组：12.3%）的增加相关。此外，在BMI>25类别中，PhA的增加与Plt（16.7%）、淋巴细胞（5.6%）和PHR（5.2%）的增加相关。此外，PhA每增加一个单位，RPR下降（正常体重组：7.4%，BMI>25组：6.6%）。ECW/TBW每增加一个单位，与Hgb（正常体重组：19.9%，BMI>25组：17.3%）和Hct（正常体重组：17.8%，BMI>25组：17.6%）的下降相关。这也与正常体重类别中WBC下降（9.6%）相关。此外，在BMI>25类别中，随着ECW/TBW的增加，Plt（5.5%）、RLR（6.5%）、RPR（6.9%）、GLR（5.9%）、粒细胞（7.5%）和淋巴细胞（8.3%）下降。研究结果显示，ECW/TBW与血液学标志物的相关性比PhA更强，这些关联在正常体重个体中尤为显著。这些结果凸显了进一步研究以探索驱动这些关系的潜在机制的必要性。
