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血液透析中血液接触激活的研究。

Studies of contact activation of blood in haemodialysis.

作者信息

Wardle E N, Piercy D A

出版信息

J Clin Pathol. 1972 Dec;25(12):1045-9. doi: 10.1136/jcp.25.12.1045.

DOI:10.1136/jcp.25.12.1045
PMID:4655858
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC477617/
Abstract

A study of patients on Kiil and Travenol coil dialysis has shown that kallikrein esterase, the kinin precursor, is increased in the venous blood during dialysis and that this is accompanied by an increase in the venous effluent of the dialysers. In addition Hageman factor depletion and an increase of platelet factor 4 has been found in the venous effluent. Such studies indicate surface activation of coagulation in the dialysers and will be of use in future studies of the suitability of different dialysers.

摘要

一项针对接受基尔(Kiil)和特拉韦诺尔(Travenol)盘管透析患者的研究表明,激肽原酶(激肽前体)在透析期间静脉血中含量增加,且透析器静脉流出液也随之增加。此外,已发现静脉流出液中有哈格曼因子消耗以及血小板因子4增加。此类研究表明透析器中存在凝血的表面激活现象,这将有助于未来对不同透析器适用性的研究。

相似文献

1
Studies of contact activation of blood in haemodialysis.血液透析中血液接触激活的研究。
J Clin Pathol. 1972 Dec;25(12):1045-9. doi: 10.1136/jcp.25.12.1045.
2
Defective esterase and kinin-forming activity in human Fletcher trait plasma. A fraction rich in kallikreinlike activity.人类弗莱彻性状血浆中酯酶和激肽形成活性缺陷。富含激肽释放酶样活性的组分。
Circ Res. 1974 May;34(5):652-62. doi: 10.1161/01.res.34.5.652.
3
The mode of action of Hageman factor in the release of plasma kinin.哈格曼因子在血浆激肽释放中的作用方式。
J Physiol. 1960 May;151(2):238-52. doi: 10.1113/jphysiol.1960.sp006434.
4
[The mechanism of activation of kallikrein-kinin system in the plasma of patients with atopic allergic diseases].[特应性过敏性疾病患者血浆中激肽释放酶-激肽系统的激活机制]
Vopr Med Khim. 1988 Nov-Dec;34(6):89-94.
5
Chromogenic peptide substrate assays in patients with multiple trauma.
Acta Chir Scand Suppl. 1982;509:69-72.
6
Relationship between kallikrein release and factor XII in normal persons and carriers of the Hageman trait.正常人及哈格曼特性携带者中激肽释放酶释放与因子XII之间的关系。
Thromb Haemost. 1979 Dec 21;42(4):1286-8.
7
[Characteristics of contact activation of rabbit blood (kallikrein and plasmin systems].[兔血接触激活的特征(激肽释放酶和纤溶酶系统)]
Biull Eksp Biol Med. 1976;81(4):390-2.
8
Fletcher factor deficiency. A diminished rate of Hageman factor activation caused by absence of prekallikrein with abnormalities of coagulation, fibrinolysis, chemotactic activity, and kinin generation.弗莱彻因子缺乏症。由于缺乏前激肽释放酶导致哈格曼因子激活速率降低,伴有凝血、纤维蛋白溶解、趋化活性和激肽生成异常。
J Clin Invest. 1974 Feb;53(2):622-33. doi: 10.1172/JCI107597.
9
[Changes in the kallikrein-kinin system in chronic hemodialysis patients].
Z Urol Nephrol. 1982 Feb;75(2):81-4.
10
Improved methods to assay contact activation.检测接触激活的改进方法。
Adv Biosci. 1978 Jul 22;17:271-80.

引用本文的文献

1
Comparison of haemoperfusion and haemodialysis in the therapy of barbiturate intoxication in dogs.血液灌流与血液透析治疗犬巴比妥类药物中毒的比较
Arch Toxikol. 1973;31(2):163-74. doi: 10.1007/BF00310394.
2
Effect of heparin and prostacyclin-heparin infusion on blood coagulation in haemodialysed patients.肝素和前列环素-肝素输注对血液透析患者血液凝固的影响。
Int Urol Nephrol. 1991;23(1):89-96. doi: 10.1007/BF02549733.

本文引用的文献

1
A new method for the determination of fibrinogen in small samples of plasma.一种测定少量血浆样本中纤维蛋白原的新方法。
J Lab Clin Med. 1951 Feb;37(2):316-20.
2
THE TRANSFER OF MACROMOLECULES IN AN ARTIFICIAL KIDNEY.
Trans Am Soc Artif Intern Organs. 1965;11:95-8. doi: 10.1097/00002480-196504000-00019.
3
Alterations in blood coagulation and hemostasis during extracorporeal circulation. II.体外循环期间血液凝固和止血的改变。II.
Can Med Assoc J. 1962 Oct 20;87(16):859-64.
4
On the relationship between plasmin and kinin.关于纤溶酶与激肽之间的关系。
Ann N Y Acad Sci. 1963 Feb 4;104:53-68. doi: 10.1111/j.1749-6632.1963.tb17652.x.
5
The interrelationship of coagulation of plasma and release of peptides.血浆凝固与肽释放之间的相互关系。
Ann N Y Acad Sci. 1963 Feb 4;104:133-45. doi: 10.1111/j.1749-6632.1963.tb17659.x.
6
Anti-heparin agents as inhibitors of plasma kinin formation.作为血浆激肽形成抑制剂的抗肝素剂。
Nature. 1962 May 19;194:689. doi: 10.1038/194689a0.
7
Pathogenesis of venous thrombosis in relation to its prevention by dextran and heparin.
J Lab Clin Med. 1965 Oct;66(4):604-12.
8
Red blood cell destruction in hemodialysis.血液透析中的红细胞破坏
Trans Am Soc Artif Intern Organs. 1969;15:50-4.
9
Alterations in fibrinolysis and coagulation associated with cardiopulmonary bypass.与体外循环相关的纤维蛋白溶解和凝血改变。
J Thorac Cardiovasc Surg. 1968 Dec;56(6):869-78.
10
The effect of chemical structure and surface properties of synthetic polymers on the coagulation of blood. II. Protein and platelet interaction with polymer surfaces.
Trans Am Soc Artif Intern Organs. 1968;14:250-5.