脑室内注射甲硫氨酸脑啡肽对小鼠应激诱导的皮质酮分泌的影响。
The effect of intracerebroventricular administration of methionine-enkephalin on the stress-induced secretion of corticosterone in mice.
作者信息
Gibson A, Ginsburg M, Hall M, Hart S L
出版信息
Br J Pharmacol. 1979 Jun;66(2):164-6. doi: 10.1111/j.1476-5381.1979.tb13660.x.
Abstract
Ether stress or intracerebroventricular (i.c.v.) administration of saline, met-enkephalin, or naltrexone raised plasma corticosterone levels in mice. The response to ether stress was abolished by a preceding ether stress or by pretreatment with i.c.v. saline or naltrexone. However, following i.c.v. met-enkephalin, plasma corticosterone was significantly elevated by ether stress, the effect being blocked by simultaneous injection of met-enkephalin and naltrexone. Met-enkephalin appears to prevent fast-feedback inhibition of the hypothalamus-pituitary-adrenal system.
摘要
乙醚应激或脑室内（i.c.v.）注射生理盐水、甲硫氨酸脑啡肽或纳曲酮可提高小鼠血浆皮质酮水平。对乙醚应激的反应可被先前的乙醚应激或脑室内注射生理盐水或纳曲酮预处理所消除。然而，在脑室内注射甲硫氨酸脑啡肽后，乙醚应激可使血浆皮质酮显著升高，同时注射甲硫氨酸脑啡肽和纳曲酮可阻断该效应。甲硫氨酸脑啡肽似乎可防止下丘脑-垂体-肾上腺系统的快速反馈抑制。
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本文引用的文献
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The estimation of small amounts of corticosterone in rat plasma.大鼠血浆中少量皮质酮的测定。
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Pharmacological effects produced by intracerebral injection of drugs in the conscious mouse.清醒小鼠脑内注射药物所产生的药理效应。
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Foot shock induced stress decreases leu5-enkephalin immunoreactivity in rat hypothalamus.足部电击诱导的应激会降低大鼠下丘脑亮氨酸脑啡肽免疫反应性。
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