长时间冷应激和反复游泳应激期间大鼠去甲肾上腺素的释放
Noradrenaline release in rats during prolonged cold-stress and repeated swim-stress.
作者信息
Benedict C R, Fillenz M, Stanford C
出版信息
Br J Pharmacol. 1979 Aug;66(4):521-4. doi: 10.1111/j.1476-5381.1979.tb13689.x.
Abstract
1 Plasma noradrenaline concentration in rats was measured during prolonged cold-stress and repeated swim-stress. 2 Cold exposure for 6 h caused a rise in plasma noradrenaline which reached a peak at 4 h. 3 Administration of desmethylimipramine and normetanephrine to block neuronal and extra-neuronal uptake of noradrenaline raised plasma noradrenaline concentration without changing the pattern of the response to cold exposure. 4 Repeated cold exposure on subsequent days produced no change in the pattern of plasma noradrenaline concentration. 5 Five successive 1-min swims at 30-min intervals caused a rise in plasma noradrenaline concentration which was maximal after the third swim. 6 It is suggested that prolonged and repeated activation of sympathetic nerve terminals leads to a decline in noradrenaline release.
摘要
- 在长时间冷应激和反复游泳应激期间，对大鼠血浆去甲肾上腺素浓度进行了测量。2. 冷暴露6小时导致血浆去甲肾上腺素升高，在4小时达到峰值。3. 给予去甲丙咪嗪和去甲变肾上腺素以阻断去甲肾上腺素的神经元和非神经元摄取，可提高血浆去甲肾上腺素浓度，而不改变对冷暴露的反应模式。4. 在随后的几天中反复冷暴露，血浆去甲肾上腺素浓度模式没有变化。5. 每隔30分钟连续进行5次1分钟的游泳，导致血浆去甲肾上腺素浓度升高，在第三次游泳后达到最大值。6. 提示交感神经末梢的长期反复激活导致去甲肾上腺素释放减少。
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