组蛋白乙酰化与激素作用。17β-雌二醇对大鼠子宫组蛋白乙酰化的早期影响。
Histone acetylation and hormone action. Early effects of oestradiol-17beta on histone acetylation in rat uterus.
作者信息
Libby P R
出版信息
Biochem J. 1972 Dec;130(3):663-9. doi: 10.1042/bj1300663.
Abstract
The effect of oestradiol treatment on the acetylation of histones of the immature rat uterus has been studied. A 10mug dose of oestradiol causes a 70% increase at 5min and a 140% increase at 10min after administration in the labelling of the histone fraction F2+F3. No effect of oestradiol is seen on the labelling of histones F1 or acidic non-histone chromatin proteins. The oestradiol stimulation is seen in animals pretreated with either cycloheximide or actinomycin D. The stimulation of labelling caused by oestradiol is completely abolished by pretreatment of the animals with the anti-oestrogen, nafoxidine. The stimulation is given by lower doses of oestradiol, by stilboestrol and oestriol, but is not given by testosterone. These results suggest that stimulation of histone acetylation in the uterus is the earliest known effect of the hormone on its target tissue.
摘要
已对雌二醇处理对未成熟大鼠子宫组蛋白乙酰化的影响进行了研究。给予10微克剂量的雌二醇后，在5分钟时组蛋白组分F2 + F3的标记增加70%，在10分钟时增加140%。未观察到雌二醇对组蛋白F1或酸性非组蛋白染色质蛋白的标记有影响。在用环己酰亚胺或放线菌素D预处理的动物中也可见到雌二醇的刺激作用。用抗雌激素药物萘福昔定预处理动物后，雌二醇引起的标记刺激作用完全消失。较低剂量的雌二醇、己烯雌酚和雌三醇可产生刺激作用，但睾酮则无此作用。这些结果表明，子宫中组蛋白乙酰化的刺激是该激素对其靶组织已知的最早作用。
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本文引用的文献
1
The prolonged treatment of castrated and ovariectomized rats with testosterone propionate.用丙酸睾酮对去势大鼠和去卵巢大鼠进行长期治疗。
Biochem J. 1937 Mar;31(3):475-85. doi: 10.1042/bj0310475.
2
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
3
Improved fractionations of arginine-rich histones from calf thymus.小牛胸腺富含精氨酸组蛋白的改良分级分离法。
Biochem J. 1960 Dec;77(3):631-6. doi: 10.1042/bj0770631.
4
The electrophoresis of histones in polyacrylamide gel and their quantitative determination.组蛋白在聚丙烯酰胺凝胶中的电泳及其定量测定。
Biochem J. 1967 Jul;104(1):78-82. doi: 10.1042/bj1040078.
5
Hydrocortisone effect upon the phytohemagglutin-stimulated acetylation of histones in human lymphocytes.氢化可的松对人淋巴细胞中植物血凝素刺激的组蛋白乙酰化的影响。
Biochim Biophys Acta. 1969 Mar 18;179(1):214-20. doi: 10.1016/0005-2787(69)90138-5.
6
High resolution acrylamide gel electrophoresis of histones.组蛋白的高分辨率丙烯酰胺凝胶电泳
Arch Biochem Biophys. 1969 Mar;130(1):337-46. doi: 10.1016/0003-9861(69)90042-3.
7
Histone acetylation: cytological evidence in human lymphocytes.组蛋白乙酰化：人类淋巴细胞中的细胞学证据
Exp Cell Res. 1969 Feb;54(2):257-60. doi: 10.1016/0014-4827(69)90245-6.
8
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9
The methylation of histones during regeneration of the liver.肝脏再生过程中组蛋白的甲基化作用。
J Biol Chem. 1968 Feb 25;243(4):707-15.
10
A method for the selective extraction of histone fractions f2(a)1 and f2(a)2 from calf thymus deoxyribonucleoprotein at pH7.一种在pH7条件下从牛胸腺脱氧核糖核蛋白中选择性提取组蛋白组分f2(a)1和f2(a)2的方法。
Biochem J. 1967 Nov;105(2):611-4. doi: 10.1042/bj1050611.
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