组蛋白乙酰化与激素作用。醛固酮对大鼠肾脏组蛋白乙酰化的早期影响。
Histone acetylation and hormone action. Early effects of aldosterone on histone acetylation in rat kidney.
作者信息
Libby P R
出版信息
Biochem J. 1973 Aug;134(4):907-12. doi: 10.1042/bj1340907.
Abstract
Histone acetylation in the kidney of the adrenalectomized rat was increased 5 min after a physiological dose of aldosterone. The increase was exclusively in the histone F2a1. The increase in histone acetylation was given by 9alpha-fluorocortisol, deoxycorticosterone and cortisol, but not by progesterone. The increase in histone acetylation was abolished by prior treatment of the animals with the anti-mineralocorticoid agent, SC14266 [potassium 3-(3-oxo-17beta-hydroxy-4,6-androstadien-17-yl) propionate]; the basal degree of histone acetylation was unaffected. Pretreatment of the animals with actinomycin D or cyclo-heximide did not affect the stimulation, showing the stimulation was not due to increased synthesis of enzyme.
摘要
生理剂量的醛固酮作用5分钟后，肾上腺切除大鼠肾脏中的组蛋白乙酰化增加。这种增加仅发生在组蛋白F2a1中。9α-氟皮质醇、脱氧皮质酮和皮质醇可使组蛋白乙酰化增加，但孕酮则不能。用抗盐皮质激素药物SC14266[3-(3-氧代-17β-羟基-4,6-雄甾二烯-17-基)丙酸酯钾]预先处理动物后，组蛋白乙酰化的增加被消除；组蛋白乙酰化的基础水平未受影响。用放线菌素D或环己酰亚胺预先处理动物不影响这种刺激作用，表明这种刺激不是由于酶合成增加所致。
相似文献
1
Histone acetylation and hormone action. Early effects of aldosterone on histone acetylation in rat kidney.组蛋白乙酰化与激素作用。醛固酮对大鼠肾脏组蛋白乙酰化的早期影响。
Biochem J. 1973 Aug;134(4):907-12. doi: 10.1042/bj1340907.
2
Induction of RNA and protein synthesis in the action of aldosterone in the rat.醛固酮对大鼠作用中RNA和蛋白质合成的诱导
Am J Physiol. 1967 Oct;213(4):954-62. doi: 10.1152/ajplegacy.1967.213.4.954.
3
Histone acetylation and hormone action. Early effects of oestradiol-17beta on histone acetylation in rat uterus.组蛋白乙酰化与激素作用。17β-雌二醇对大鼠子宫组蛋白乙酰化的早期影响。
Biochem J. 1972 Dec;130(3):663-9. doi: 10.1042/bj1300663.
4
Effect of mineralocorticoid agonists and antagonists on binding of 3 H-aldosterone to adrenalectomized rat kidney plasma membranes.盐皮质激素激动剂和拮抗剂对3H-醛固酮与肾上腺切除大鼠肾质膜结合的影响。
Life Sci I. 1972 May 15;11(10):461-73. doi: 10.1016/0024-3205(72)90196-8.
5
Aldosterone-induced alterations in the synthesis of renal cortical chromatin components and acetylation of histones.醛固酮引起的肾皮质染色质成分合成及组蛋白乙酰化的改变。
Proc Soc Exp Biol Med. 1972 Oct;141(1):14-20. doi: 10.3181/00379727-141-36707.
6
Oxidative response to aldosterone of pyridine nucleotide in rat kidney in situ.大鼠肾脏原位吡啶核苷酸对醛固酮的氧化反应
Am J Physiol. 1977 Apr;232(4):E401-7. doi: 10.1152/ajpendo.1977.232.4.E401.
7
Induction of flavokinase (EC 2.7.1.26) by aldosterone in the rat kidney.醛固酮对大鼠肾脏中黄素激酶（EC 2.7.1.26）的诱导作用。
Endocrinology. 1985 Mar;116(3):879-88. doi: 10.1210/endo-116-3-879.
8
Studies on ribonucleic acid turnover in rat organs: effects of cortisol, actinomycin D, and cycloheximide.大鼠器官中核糖核酸周转的研究：皮质醇、放线菌素D和环己酰亚胺的作用。
Endocrinol Jpn. 1972 Jun;19(3):225-8. doi: 10.1507/endocrj1954.19.225.
9
Effects of aldosterone on acetylation and phosphorylation of chromosomal proteins.醛固酮对染色体蛋白乙酰化和磷酸化的影响。
Endocrinology. 1973 Nov;93(5):1025-34. doi: 10.1210/endo-93-5-1025.
10
Effect of administered mineralocorticoids or ACTH in pregnant women. Attenuation of kaliuretic influence of mineralocorticoids during pregnancy.给予盐皮质激素或促肾上腺皮质激素对孕妇的影响。孕期盐皮质激素排钾作用的减弱。
J Clin Invest. 1972 Jun;51(6):1301-9. doi: 10.1172/JCI106926.
引用本文的文献
1
Protein acetylation.蛋白质乙酰化
Mol Cell Biochem. 1982 Aug 6;46(3):129-53. doi: 10.1007/BF00239663.
2
N-acetylation of p-amino-hippurate in kidneys with renal artery stenosis and in patients suffering from severe essential hypertension.肾动脉狭窄患者及重度原发性高血压患者肾脏中对氨基马尿酸的N - 乙酰化作用
Klin Wochenschr. 1974 Oct 1;52(19):913-5. doi: 10.1007/BF01468936.
3
The beta-globin domain in immature chicken erythrocytes: enhanced solubility is coincident with histone hyperacetylation.未成熟鸡红细胞中的β-珠蛋白结构域：溶解性增强与组蛋白高度乙酰化同时发生。
Nucleic Acids Res. 1986 Feb 25;14(4):1667-82. doi: 10.1093/nar/14.4.1667.
4
On the biological role of histone acetylation.论组蛋白乙酰化的生物学作用。
Biochem J. 1990 Jan 1;265(1):23-38. doi: 10.1042/bj2650023.
5
On the mechanism of lanthanide-induced liver toxicity.关于镧系元素诱导的肝毒性机制。
Arch Toxicol. 1976 Sep 15;36(1):1-17. doi: 10.1007/BF00277559.
6
Deficiency in histone acetylation in nontransforming host range mutants of polyoma virus.多瘤病毒非转化宿主范围突变体中组蛋白乙酰化缺陷。
Proc Natl Acad Sci U S A. 1976 Apr;73(4):1092-6. doi: 10.1073/pnas.73.4.1092.
本文引用的文献
1
Renal gluconeogenesis in the intact dog.完整犬的肾糖异生
Am J Physiol. 1951 May;165(2):423-8. doi: 10.1152/ajplegacy.1951.165.2.423.
2
STIMULATION IN VIVO OF RENAL RNA-SYNTHESIS BY ALDOSTERONE.醛固酮对肾RNA合成的体内刺激作用。
Proc Soc Exp Biol Med. 1965 Jun;119:308-11. doi: 10.3181/00379727-119-30164.
3
CORTICOSTEROIDS AND ENZYME ACTIVITY.
Vitam Horm. 1963;21:135-214. doi: 10.1016/s0083-6729(08)60241-1.
4
[The action of electrocortin in the glycogen test].[电皮质素在糖原试验中的作用]
Experientia. 1954 Mar 15;10(3):142. doi: 10.1007/BF02158522.
5
Organ specificity of histone Acetyltransferases.组蛋白乙酰转移酶的器官特异性。
FEBS Lett. 1971 Mar 22;13(5):306-308. doi: 10.1016/0014-5793(71)80247-8.
6
Induction of RNA and protein synthesis in the action of aldosterone in the rat.醛固酮对大鼠作用中RNA和蛋白质合成的诱导
Am J Physiol. 1967 Oct;213(4):954-62. doi: 10.1152/ajplegacy.1967.213.4.954.
7
8
Hydrocortisone effect upon the phytohemagglutin-stimulated acetylation of histones in human lymphocytes.氢化可的松对人淋巴细胞中植物血凝素刺激的组蛋白乙酰化的影响。
Biochim Biophys Acta. 1969 Mar 18;179(1):214-20. doi: 10.1016/0005-2787(69)90138-5.
9
Histone acetylation: cytological evidence in human lymphocytes.组蛋白乙酰化：人类淋巴细胞中的细胞学证据
Exp Cell Res. 1969 Feb;54(2):257-60. doi: 10.1016/0014-4827(69)90245-6.
10
In vitro inhibition of aldosterone-stimulated sodium transport by steroidal spirolactones.甾体类螺内酯对醛固酮刺激的钠转运的体外抑制作用。
Mol Pharmacol. 1968 May;4(3):224-37.
Zotero 插件