Borer K T, Trulson M E, Kuhns L R
Brain Res Bull. 1979 Mar-Apr;4(2):239-47. doi: 10.1016/0361-9230(79)90288-0.
Rostral septal lesions accelerate somatic growth in adult hamsters. This study tested the hypothesis that this effect results from damage to fibers of passage by observing the effects of transections of septohippocampal and septohypothalamic connections on growth. We attempted to identify these fibers further by (a) measuring spectrofluorometrically changes in the monoamine concentrations in hippocampus, cerebral cortex, corpus striatum, and diencephalon, (b) staining the degenerating axons after septal lesions and the two cuts, and (c) examining the correspondence between such damage and the acceleration of growth. Both knife cuts accelerated somatic growth and were associated (as well as septal lesions) with significant depletions of serotonin (-27 to -57%) and norepinephrine (-27 to -60%) in the hippocampus, with less consistent depletions of these monoamines in the cerebral cortex, and with no changes in regional dopamine content. All three procedures were associated with degeneration in the hippocampal formation and its fiber systems. Thus, fibers interconnecting hippocampus and brainstem, and passing through septum, exert tonic suppression over somatic growth in adult hamsters.
吻侧隔区损伤会加速成年仓鼠的躯体生长。本研究通过观察海马和下丘脑隔区连接横断对生长的影响，检验了这种效应是由传导纤维受损所致的假说。我们试图通过以下方法进一步鉴定这些纤维：(a) 用荧光分光光度法测量海马、大脑皮层、纹状体和间脑中单胺浓度的变化；(b) 对隔区损伤及两处横断后的变性轴突进行染色；(c) 检查这种损伤与生长加速之间的对应关系。两处横断均加速了躯体生长，并且（与隔区损伤一样）与海马中血清素显著减少（-27%至-57%）和去甲肾上腺素显著减少（-27%至-60%）有关，大脑皮层中这些单胺的减少不太一致，且区域多巴胺含量无变化。所有这三个操作都与海马结构及其纤维系统的变性有关。因此，连接海马和脑干并穿过隔区的纤维对成年仓鼠的躯体生长发挥着紧张性抑制作用。
