海马横断成年仓鼠血清生长激素增加及体细胞生长加快。

Increased serum growth hormone and somatic growth in adult hamsters with hippocampal transections.

作者信息

Borer K T, Kelch R P, Peugh J, Huseman C

出版信息

Neuroendocrinology. 1979;29(1):22-33. doi: 10.1159/000122901.

Abstract

Somatic, endocrine, and behavioral correlates of growth and levels of voluntary running activity were measured in adult hamsters with hippocampal transections (HIPPO cuts) or in controls with transections of overlying cortex. Significant increase in serum concentration of growth hormone (GH) and decrease in pituitary concentration of GH were measured in HIPPO hamsters with a homologous radioimmunoassay method for hamster GH. HIPPO hamsters had increased: serum insulin concentration in fed state, food consumption, ponderal and linear growth, and percentage of body fat, and decreased levels of voluntary activity. Similarities between growth acceleration after HIPPO cuts and lesions of rostral medial septum suggest that fibers interconnecting, or passing through, the hippocampal formation and septum inhibit growth in adult hamsters.

摘要

在成年仓鼠中，测量了海马横断（海马切断）或覆盖皮质横断的对照仓鼠的生长、自愿跑步活动水平的躯体、内分泌和行为相关性。采用同源放射免疫分析法测定仓鼠生长激素（GH），发现海马横断的仓鼠血清GH浓度显著升高，垂体GH浓度降低。海马横断的仓鼠在进食状态下血清胰岛素浓度增加、食物摄入量增加、体重和线性生长增加、体脂百分比增加，且自愿活动水平降低。海马切断后生长加速与 Rostral 内侧隔损伤之间的相似性表明，连接或穿过海马结构和隔的纤维抑制成年仓鼠的生长。