Borer K T, Peters N L, Kelch R P, Tsai A C, Holder S
J Comp Physiol Psychol. 1979 Oct;93(5):907-18. doi: 10.1037/h0077624.
The mechanism responsible for weight stability in adult hamsters was investigated by (a) transecting the dorsoventrally oriented nerve pathways between the septal area and hypothalamus (SH cuts) and (b) partitioning the observed increases in the rate of weight gain into three contributory components: changes in somatic growth, in body fatness, and in energy expended as voluntary activity on horizontal disks. Between 60% and 70% of the weight increase after SH cuts was due to acquisition of lean body mass, and 30%-40% of weight increase consisted of excess body fat. After SH cuts, serum growth hormone and insulin concentrations were increased on Day 14, food intake was increased between Day 2 and Day 42, skeletal lengths were greater on Day 77, and voluntary activity levels were 84% lower on Days 10-45, relative to control hamsters. It is concluded that dorsoventrally oriented nerve pathways in the septal area are involved in the control of growth, maintenance of body fat reserves, and voluntary activity and that they contribute to the maintenance of stable body weight in adult hamsters.
（a）横断隔区与下丘脑之间背腹走向的神经通路（SH切断）；（b）将观察到的体重增加速率的上升分为三个促成部分：体细胞生长、体脂含量及在水平圆盘上作为自发活动所消耗能量的变化。SH切断后，60%至70%的体重增加归因于瘦体重的增加，30%至40%的体重增加为多余体脂。SH切断后，第14天血清生长激素和胰岛素浓度升高，第2天至第42天食物摄入量增加，第77天骨骼长度增加，相对于对照仓鼠，第10天至第45天自发活动水平降低84%。得出的结论是，隔区背腹走向的神经通路参与生长控制、体脂储备维持及自发活动，并且它们有助于成年仓鼠维持稳定体重。
