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Kinetics of a new antimalarial, mefloquine.

作者信息

Desjardins R E, Pamplin C L, von Bredow J, Barry K G, Canfield C J

出版信息

Clin Pharmacol Ther. 1979 Sep;26(3):372-9. doi: 10.1002/cpt1979263372.

DOI:10.1002/cpt1979263372
PMID:466930
Abstract
摘要

相似文献

1
Kinetics of a new antimalarial, mefloquine.新型抗疟药甲氟喹的动力学
Clin Pharmacol Ther. 1979 Sep;26(3):372-9. doi: 10.1002/cpt1979263372.
2
[Metabolism of Ro 21-5998 (mefloquine) in the rat (author's transl)].
Arzneimittelforschung. 1980;30(1):60-7.
3
Studies of the disposition and metabolism of mefloquine HCl (WR 142,490), a quinolinemethanol antimalarial, in the rat. Limited studies with an analog, WR 30,090.盐酸甲氟喹（WR 142,490，一种喹啉甲醇类抗疟药）在大鼠体内的处置和代谢研究。对类似物WR 30,090的有限研究。
Drug Metab Dispos. 1975 May-Jun;3(3):198-210.
4
Mefloquine, a clinically useful quinolinemethanol antimalarial which does not significantly bind to DNA.
Nature. 1975 Apr 17;254(5501):632-4. doi: 10.1038/254632a0.
5
Kinetic studies of mefloquine and of one of its metabolites, Ro 21-5104, in the dog and in man.
Acta Trop. 1980 Sep;37(3):238-42.
6
Intragastric mefloquine is absorbed rapidly in patients with cerebral malaria.脑型疟患者胃内的甲氟喹吸收迅速。
Am J Trop Med Hyg. 1985 Nov;34(6):1028-36. doi: 10.4269/ajtmh.1985.34.1028.
7
Pharmacokinetics of antimalarial drugs: their therapeutic and toxicological implications.
Ann Ist Super Sanita. 1985;21(3):315-25.
8
The antimalarial drug mefloquine binds to membrane phospholipids.抗疟药物甲氟喹与膜磷脂结合。
Antimicrob Agents Chemother. 1982 Apr;21(4):581-6. doi: 10.1128/AAC.21.4.581.
9
Multiple-dose pharmacokinetics of the antimalarial drug Fansimef (pyrimethamine + sulfadoxine + mefloquine) in healthy subjects.抗疟药物 Fansimef（乙胺嘧啶+磺胺多辛+甲氟喹）在健康受试者中的多剂量药代动力学。
Chemotherapy. 1987;33(1):1-8. doi: 10.1159/000238468.
10
Binding of antimalarial drugs to hemozoin from Plasmodium berghei.抗疟药物与伯氏疟原虫疟色素的结合
Experientia. 1980 Sep 15;36(9):1063-4. doi: 10.1007/BF01965970.

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Development of a physiologically based pharmacokinetic model for mefloquine and its application alongside a clinical effectiveness model to select an optimal dose for prevention of malaria in young Caucasian children.开发一种基于生理学的甲氟喹药代动力学模型，并将其与临床效果模型一起用于选择预防白人儿童疟疾的最佳剂量。
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Discovery of compounds blocking the proliferation of Toxoplasma gondii and Plasmodium falciparum in a chemical space based on piperidinyl-benzimidazolone analogs.基于哌啶基 - 苯并咪唑酮类似物在化学空间中发现可阻断刚地弓形虫和恶性疟原虫增殖的化合物。
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