新型抗疟药甲氟喹的动力学 - Suppr

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Kinetics of a new antimalarial, mefloquine.

作者信息

Desjardins R E, Pamplin C L, von Bredow J, Barry K G, Canfield C J

出版信息

Clin Pharmacol Ther. 1979 Sep;26(3):372-9. doi: 10.1002/cpt1979263372.

DOI:10.1002/cpt1979263372

PMID:466930

Abstract

摘要

相似文献

Kinetics of a new antimalarial, mefloquine.新型抗疟药甲氟喹的动力学

Clin Pharmacol Ther. 1979 Sep;26(3):372-9. doi: 10.1002/cpt1979263372.

[Metabolism of Ro 21-5998 (mefloquine) in the rat (author's transl)].

Arzneimittelforschung. 1980;30(1):60-7.

Studies of the disposition and metabolism of mefloquine HCl (WR 142,490), a quinolinemethanol antimalarial, in the rat. Limited studies with an analog, WR 30,090.盐酸甲氟喹（WR 142,490，一种喹啉甲醇类抗疟药）在大鼠体内的处置和代谢研究。对类似物WR 30,090的有限研究。

Drug Metab Dispos. 1975 May-Jun;3(3):198-210.

Mefloquine, a clinically useful quinolinemethanol antimalarial which does not significantly bind to DNA.

Nature. 1975 Apr 17;254(5501):632-4. doi: 10.1038/254632a0.

Kinetic studies of mefloquine and of one of its metabolites, Ro 21-5104, in the dog and in man.

Acta Trop. 1980 Sep;37(3):238-42.

Intragastric mefloquine is absorbed rapidly in patients with cerebral malaria.脑型疟患者胃内的甲氟喹吸收迅速。

Am J Trop Med Hyg. 1985 Nov;34(6):1028-36. doi: 10.4269/ajtmh.1985.34.1028.

Pharmacokinetics of antimalarial drugs: their therapeutic and toxicological implications.

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The antimalarial drug mefloquine binds to membrane phospholipids.抗疟药物甲氟喹与膜磷脂结合。

Antimicrob Agents Chemother. 1982 Apr;21(4):581-6. doi: 10.1128/AAC.21.4.581.

Multiple-dose pharmacokinetics of the antimalarial drug Fansimef (pyrimethamine + sulfadoxine + mefloquine) in healthy subjects.抗疟药物 Fansimef（乙胺嘧啶+磺胺多辛+甲氟喹）在健康受试者中的多剂量药代动力学。

Chemotherapy. 1987;33(1):1-8. doi: 10.1159/000238468.

Binding of antimalarial drugs to hemozoin from Plasmodium berghei.抗疟药物与伯氏疟原虫疟色素的结合

Experientia. 1980 Sep 15;36(9):1063-4. doi: 10.1007/BF01965970.

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