Koshiver J, Moore D
Comput Programs Biomed. 1979 Jul;10(1):61-5. doi: 10.1016/0010-468x(79)90052-7.
We describe a FORTRAN computer program for fitting the logistic distribution function: (formula: see text) Where x represents dose or time, to dose-response data. The program determines both weighted least squares and maximum likelihood estimates for the parameters alpha and beta. It also calculates the standard errors of alpha and beta under both estimation methods, as well as the median lethal dose (LD50) and its standard error. Dose--response curves found by both fitting methods can be plotted as well as the 95% confidence bands for these lines.
我们描述了一个用于拟合逻辑分布函数的FORTRAN计算机程序：（公式：见正文）其中x代表剂量或时间，用于剂量反应数据。该程序确定参数α和β的加权最小二乘估计和最大似然估计。它还计算两种估计方法下α和β的标准误差，以及半数致死剂量（LD50）及其标准误差。通过两种拟合方法得到的剂量反应曲线以及这些曲线的95%置信带都可以绘制出来。
