青霉素蛋白质结合的可逆性：一项采用快速渗滤过程的体外研究。
Reversibility of protein binding of penicillins: an in vitro study employing a rapid diafiltration process.
作者信息
Barza M, Vine H, Weinstein L
出版信息
Antimicrob Agents Chemother. 1972 May;1(5):427-32. doi: 10.1128/AAC.1.5.427.
Abstract
The reversibility of human serum protein binding of oxacillin, nafcillin, and cephalothin was investigated by using a diafiltration technique. While the temperature, pH, and protein concentration were kept constant, 20% of the serum volume was exchanged every 4 to 5 min. The binding of all three drugs was rapidly reversible, and the percentage of protein binding remained the same throughout the experiment.
摘要
采用渗滤技术研究了苯唑西林、萘夫西林和头孢噻吩与人血清蛋白结合的可逆性。在温度、pH值和蛋白质浓度保持恒定的情况下，每4至5分钟更换20%的血清体积。所有三种药物的结合都是快速可逆的，并且在整个实验过程中蛋白质结合百分比保持不变。
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