Reversibility of protein binding of penicillins: an in vitro study employing a rapid diafiltration process.
作者信息
Barza M, Vine H, Weinstein L
出版信息
Antimicrob Agents Chemother. 1972 May;1(5):427-32. doi: 10.1128/AAC.1.5.427.
Abstract
The reversibility of human serum protein binding of oxacillin, nafcillin, and cephalothin was investigated by using a diafiltration technique. While the temperature, pH, and protein concentration were kept constant, 20% of the serum volume was exchanged every 4 to 5 min. The binding of all three drugs was rapidly reversible, and the percentage of protein binding remained the same throughout the experiment.
摘要
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Reversibility of protein binding of penicillins: an in vitro study employing a rapid diafiltration process.
Antimicrob Agents Chemother. 1972 May;1(5):427-32. doi: 10.1128/AAC.1.5.427.
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