Murata Y, Mita K, Miyamoto E, Ueda M
School of Pharmacy, Hokuriku University, Kanazawa, Japan.
Antimicrob Agents Chemother. 1989 Sep;33(9):1636-8. doi: 10.1128/AAC.33.9.1636.
Twenty N,N'-dialkylpolymethylendiamine derivatives were synthesized, and a study was made of their antimicrobial activities in vitro against four oral microorganisms which are related to dental caries. The maximum activity was shown by N,N'-dinonyl or N,N'-didecyl derivatives among the complete homologous series of compounds studied.
合成了20种N,N'-二烷基聚亚甲基二胺衍生物,并对其体外抗四种与龋齿相关的口腔微生物的抗菌活性进行了研究。在所研究的完整同系物系列化合物中,N,N'-二壬基或N,N'-二十二烷基衍生物表现出最大活性。