Bodey G P
Antimicrob Agents Chemother. 1972 Apr;1(4):343-7. doi: 10.1128/AAC.1.4.343.
Eight patients in protected environment units received by the oral route a solution of gentamicin and vancomycin which completely suppressed all 78 strains of bacteria originally present in their stools. However, when the solution was discontinued bacteria were cultured again from the stools of every patient. Twenty-nine of the 42 strains cultured at this time were also cultured from pretreatment specimens. Oral absorbable antibiotics were given to six of these patients, but they eliminated only 10 of the 32 strains cultured from their stools. Seven of the 16 strains which persisted became resistant to the oral absorbable antibiotic. To achieve maximum effect, oral nonabsorbable antibiotic regimens must be continued as long as the patient remains in a protected environment unit.
在保护环境病房中的8名患者口服了庆大霉素和万古霉素溶液，该溶液完全抑制了他们粪便中原本存在的所有78株细菌。然而，当停止使用该溶液后，每个患者的粪便中又培养出了细菌。此时培养出的42株细菌中有29株也在治疗前的样本中培养出来过。其中6名患者接受了口服可吸收抗生素治疗，但他们仅清除了粪便中培养出的32株细菌中的10株。持续存在的16株细菌中有7株对口服可吸收抗生素产生了耐药性。为了达到最大效果，只要患者仍在保护环境病房中，就必须持续使用口服不可吸收抗生素方案。
