Vaillier J, Donner M
Chronobiologia. 1979 Jan-Mar;6(1):9-17.
The primary immune response in inbred strain C3H/He to SRBC, or BSA is induced. The DNA, RNA, lipid precursor uptakes and total proteins are studied for 14 successive days following immunization, in splenic lymphocytes. Significant variations are noticed in the course of immune response of stimulated lymphocytes concerning their DNA, RNA, lipid and protein metabolisms respectively. The results reveal that there are several wave-metabolisms. The kinetic studies further indicate that course of different metabolisms would be of oscillatory nature. The activity peaks of synthesis may vary according to different antigens. Oscillatory systems would be 'excited' by antigenic stimulation. These results and hypotheses are discussed here.
诱导近交系C3H/He对绵羊红细胞（SRBC）或牛血清白蛋白（BSA）的初次免疫反应。在免疫后的连续14天内，研究脾淋巴细胞对DNA、RNA、脂质前体的摄取及总蛋白情况。在刺激淋巴细胞的免疫反应过程中，分别观察到其DNA、RNA、脂质和蛋白质代谢存在显著变化。结果显示存在多种波动代谢。动力学研究进一步表明，不同代谢过程具有振荡性质。合成活性峰值可能因不同抗原而异。振荡系统会被抗原刺激“激发”。在此讨论这些结果和假设。
