Reno P W, Hoffmann E M
Infect Immun. 1972 Dec;6(6):945-51. doi: 10.1128/iai.6.6.945-951.1972.
Experiments were conducted to determine the effect of specific antibody and complement on hemagglutination inhibition of influenza virus. It was found that early immunoglobulin M antibody to influenza virus inhibited the hemagglutinating capacity of the virus. When fresh guinea pig serum was added, the inhibiting capacity of the serum was elevated from four- to eightfold When guinea pig serum was treated with known complement inhibitors, it lost its capacity to enhance hemagglutination. The use of functionally purified complement components indicated that the first, second, and fourth components were necessary and sufficient for enhancement of hemagglutination inhibition by specific antibody to influenza virus.
进行了实验以确定特异性抗体和补体对流感病毒血凝抑制的影响。发现针对流感病毒的早期免疫球蛋白M抗体可抑制该病毒的血凝能力。当加入新鲜豚鼠血清时，血清的抑制能力提高了4至8倍。当用已知的补体抑制剂处理豚鼠血清时，它失去了增强血凝的能力。使用功能纯化的补体成分表明，第一、第二和第四成分对于增强针对流感病毒的特异性抗体的血凝抑制作用是必要且充分的。
