不同相对亲和力的抗体库的抗原结合特性。
The antigen-binding characteristics of antibody pools of different relative affinity.
作者信息
Steward M W, Petty R E
出版信息
Immunology. 1972 Dec;23(6):881-7.
Abstract
The interstrain differences in relative affinity of mouse anti-HSA antibody previously shown by studies at equilibrium are also observed when rates of association and dissociation and avidity indices are measured. Marked differences are demonstrated in the binding characteristics of high and low relative affinity antibody to both protein and hapten antigens. These results are explained on the basis of heterogeneity of antibody-binding affinity.
摘要
在测量结合和解离速率以及亲和力指数时，也观察到了先前在平衡研究中所显示的小鼠抗人血清白蛋白（HSA）抗体相对亲和力的菌株间差异。高相对亲和力和低相对亲和力抗体与蛋白质和半抗原抗原的结合特性存在显著差异。这些结果基于抗体结合亲和力的异质性得到了解释。
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