氯氮平对脑内儿茶酚胺能神经元系统的影响。
Effects of clozapine on cerebral catecholaminergic neurone systems.
作者信息
Bartholini G, Haefely W, Jalfre M, Keller H H, Pletscher A
出版信息
Br J Pharmacol. 1972 Dec;46(4):736-40. doi: 10.1111/j.1476-5381.1972.tb06898.x.
Abstract
- Clozapine, a dibenzodiazepine derivative claimed to possess antipsychotic properties in man without producing extrapyramidal disorders, greatly increased the turnover of cerebral dopamine in the rat.2. The drug itself was virtually devoid of cataleptigenic activity in rats; however, it antagonized prochlorperazine-induced catalepsy.3. It is proposed that clozapine causes a blockade of striatal dopamine receptors which is of the surmountable type in contrast to that produced by cataleptigenic neuroleptics. In addition, clozapine may also increase the turnover of cerebral noradrenaline.
摘要
氯氮平是一种二苯并二氮杂卓衍生物，据称对人体具有抗精神病特性且不会引发锥体外系疾病，它能显著提高大鼠脑内多巴胺的周转率。
该药物本身在大鼠中几乎没有致僵活性；然而，它能对抗氯丙嗪诱导的僵住症。
有人提出，氯氮平导致纹状体多巴胺受体的阻断，这种阻断与致僵性抗精神病药物产生的阻断不同，是可克服型的。此外，氯氮平还可能增加脑内去甲肾上腺素的周转率。
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2
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Acta Pharmacol Toxicol (Copenh). 1963;20:140-4. doi: 10.1111/j.1600-0773.1963.tb01730.x.
3
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