Poydock M E, Fardon J C, Gallina D, Ferro V, Heher C
Exp Cell Biol. 1979;47(3):210-7. doi: 10.1159/000162938.
The mitotic activity of the transplantable mouse tumors, Sarcoma 37, Krebs-2, and Ehrlich carcinomas, in the ascites form, were inhibited after treatment with a mixture of vitamins C and B12 with no apparent toxic side effects. These vitamins when administered alone, at the same dosage, did not seem to have any apparent effect on mitosis or the morphology of the cells studied. Microscopic examination of the stained ascites fluid taken from the mice treated with the vitamin mixture showed few tumor cells, and these in various stages of disintegration. Also, an increase in lymphocytes, monocytes and neutrophils were noticed; however, later in the experiment, no tumor cells could be found and monocytes and macrophages were abundant.
将可移植的小鼠肿瘤（腹水型肉瘤37、克雷布斯-2癌和艾氏癌）用维生素C和维生素B12的混合物处理后，其有丝分裂活性受到抑制，且无明显的毒副作用。这些维生素单独以相同剂量给药时，似乎对所研究细胞的有丝分裂或形态没有任何明显影响。对用维生素混合物处理的小鼠采集的染色腹水进行显微镜检查，发现肿瘤细胞很少，且处于不同的解体阶段。此外，还注意到淋巴细胞、单核细胞和中性粒细胞有所增加；然而，在实验后期，未发现肿瘤细胞，单核细胞和巨噬细胞大量存在。
