Sigaran M F, Con-Wong R
Gan. 1979 Jun;70(3):343-52.
It was possible to produce gastric adenocarcinoma in five of 69, healthy, young albino mice of both sexes given N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) in their drinking water at a concentration of 100 microgram/ml. The tumoral lesions were most clearly defined in the group that received MNNG for the longest period of time, that is, 68 weeks. On the other hand, in the rest of the groups, which received MNNG for fewer weeks, there were lesions found in a total of nine animals which consisted in foci of typical and atypical hyperplasia, erosion of the mucosa, and, in one animal, an adenomatous polyp. Contrary to findings in humans, intestinal metaplasia preceding or accompanying the neoplasia was found to be an inconsistent alteration and a not very frequent one.
给69只健康的年轻雌雄白化病小鼠饮用浓度为100微克/毫升的N-甲基-N'-硝基-N-亚硝基胍（MNNG），其中5只出现了胃腺癌。肿瘤病变在接受MNNG时间最长的组中最为明确，即68周。另一方面，在接受MNNG时间较短的其他组中，总共9只动物出现了病变，包括典型和非典型增生灶、黏膜糜烂，还有1只动物出现了腺瘤性息肉。与人类的发现相反，肿瘤形成之前或伴随出现的肠化生是一种不一致且不太常见的改变。
