16,16-二甲基前列腺素E2对胃黏膜屏障的作用
Effect of 16,16-dimethyl prostaglandin E2 on the gastric mucosal barrier.
作者信息
Bolton J P, Cohen M M
出版信息
Gut. 1979 Jun;20(6):513-7. doi: 10.1136/gut.20.6.513.
16,16-dimethyl prostaglandin E2 (16DM) can protect the gastric mucosa from injury and yet apparently damages the gastric mucosal barrier. The effect on the gastric mucosal barrier of 16DM (26.2 micromol/l), a dose 50 times the ED50 for inhibition of acid secretion, was investigated in Heidenhain pouches in four dogs by measuring plasma shedding from the pouches after the topical application of histamine (2.7 mmol/l) and ionic fluxes. The results were compared with those using 30% ethanol, a known barrier breaker. The topical application of histamine after three hours' perfusion with 30% ethanol led to plasma shedding at a rate of 7.5 (+/-2.6) ml/h, which was significantly greater than the rate of 1.2 (+/-1.4) ml/h after three hours' perfusion with 16DM and of 1.5 (+/-1.7) ml/h in the control group. Ethanol also caused an increase in the flux of H+, Na+, and Cl-, indicating an increase in mucosal permeability, whereas 16DM increased the flux of Na+ and Cl- but not of H+. It is concluded that 16DM does not damage the gastric mucosal barrier but stimulates the secretion of fluid containing Na+ and Cl-.
16,16 - 二甲基前列腺素E2（16DM）可保护胃黏膜免受损伤，但显然会损害胃黏膜屏障。通过测量在局部应用组胺（2.7 mmol/L）后袋囊中血浆渗出情况和离子通量，研究了16DM（26.2微摩尔/升，该剂量是抑制胃酸分泌的ED50的50倍）对四只狗海登海因小胃胃黏膜屏障的影响。将结果与使用已知的屏障破坏剂30%乙醇的结果进行比较。在用30%乙醇灌注三小时后局部应用组胺，导致血浆以7.5（±2.6）毫升/小时的速率渗出，这显著高于在用16DM灌注三小时后的1.2（±1.4）毫升/小时的速率以及对照组的1.5（±1.7）毫升/小时的速率。乙醇还导致H⁺、Na⁺和Cl⁻通量增加，表明黏膜通透性增加，而16DM增加了Na⁺和Cl⁻的通量，但未增加H⁺的通量。得出的结论是，16DM不会损害胃黏膜屏障，而是刺激含Na⁺和Cl⁻的液体分泌。
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