胃分泌抑制剂对胃黏膜屏障的作用。
Effect of gastric secretory inhibitors on the gastric mucosal barrier.
作者信息
O'Brien P E, Carter D C
出版信息
Gut. 1975 Jun;16(6):437-42. doi: 10.1136/gut.16.6.437.
Abstract
The effects of the synthetic prostaglandin 16, 16 dimethyl-E2 methyl ester (16-diMe-PGE2) and the histamine H2-receptor antagonist metiamide on the gastric mucosal barrier have been studied using the Heidenhain pouch dog model. The 16-diMe-PGE2 caused significant change in the ionic permeability of the mucosa when instilled into the pouch in a concentration of 300 mug/20 ml. Intravenous administration of 16-diMe-PGE2 did not alter the barrier nor did it alter the response of the mucosa to sodium taurocholate. Metiamide given into the pouch did not affect the mucosa barrier and the response to taurocholate was not affected when metiamide was given locally or intravenously.
摘要
利用海登海因小胃犬模型，研究了合成前列腺素16,16 - 二甲基 - E2甲酯（16 - 二甲基 - PGE2）和组胺H2受体拮抗剂甲硫米特对胃黏膜屏障的影响。当以300微克/20毫升的浓度注入小胃时，16 - 二甲基 - PGE2会引起黏膜离子通透性的显著变化。静脉注射16 - 二甲基 - PGE2不会改变屏障，也不会改变黏膜对牛磺胆酸钠的反应。注入小胃的甲硫米特不影响黏膜屏障，当局部或静脉给予甲硫米特时，对牛磺胆酸钠的反应也不受影响。
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本文引用的文献
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GASTRIC MUCOSAL INJURY BY FATTY AND ACETYLSALICYLIC ACIDS.脂肪酸和乙酰水杨酸所致的胃黏膜损伤
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Gastroenterology. 1974 Apr;66(4):517-21.
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