U - 42,126，一种新型抗代谢物抗生素：产生菌的生产、生物活性及分类学
U-42, 126, a new antimetabolite antibiotic: production, biological activity, and taxonomy of the producing microorganism.
作者信息
Hanka L J, Dietz A
出版信息
Antimicrob Agents Chemother. 1973 Mar;3(3):425-31. doi: 10.1128/AAC.3.3.425.
Abstract
A new antimetabolite antibiotic, U-42,126, was discovered by use of a specific in vitro screen. U-42,126 was produced by the fermentation of Streptomyces sviceus. Its antimicrobial activity in vitro was limited to fungi. Certain bacteria were inhibited only when cultivated in completely synthetic media. U-42,126 was active in vivo against L1210 leukemia in mice.
摘要
一种新的抗代谢物抗生素U - 42,126，是通过特定的体外筛选方法发现的。U - 42,126由灰色链霉菌发酵产生。它的体外抗菌活性仅限于真菌。某些细菌只有在完全合成培养基中培养时才会受到抑制。U - 42,126在体内对小鼠L1210白血病具有活性。
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