Bose S K, Liebhaber H
Infect Immun. 1979 Jun;24(3):953-7. doi: 10.1128/iai.24.3.953-957.1979.
The fate of lymphogranuloma venereum strain Chlamydia-infected HeLa 229 cells was examined by determining the rate of deoxyribonucleic acid synthesis and the kinetics of entry into and progression through S phase and by time-lapse cinemicrography. At an input multiplicity of 5 or less, Chlamydia-infected cells showed no inhibition of host deoxyribonucleic acid synthesis or cell cycle progression. Cinemicrography showed division of inclusion-containing cells, with one or both daughters receiving chlamydial inclusions. Analysis of the family trees indicated that the generation times of infected HeLa 229 were not altered relative to those of the uninfected cells.
通过测定脱氧核糖核酸合成速率、进入S期和在S期进展的动力学以及延时电影显微镜检查，研究了感染性病性淋巴肉芽肿衣原体的HeLa 229细胞的命运。在感染复数为5或更低时，感染衣原体的细胞未表现出对宿主脱氧核糖核酸合成或细胞周期进程的抑制。电影显微镜检查显示含包涵体的细胞发生分裂，一个或两个子代细胞都获得衣原体包涵体。系谱分析表明，感染的HeLa 229细胞的代时与未感染细胞相比没有改变。
