锌对沙眼衣原体在 McCoy 细胞、HeLa 细胞及人前列腺细胞中生长的抑制作用。
Inhibition of Chlamydia trachomatis growth in McCoy, HeLa, and human prostate cells by zinc.
作者信息
Greenberg S B, Harris D, Giles P, Martin R R, Wallace R J
出版信息
Antimicrob Agents Chemother. 1985 Jun;27(6):953-7. doi: 10.1128/AAC.27.6.953.
Abstract
Zinc salts (10(-4) and 10(-5) M) inhibited the number of Chlamydia trachomatis inclusions in McCoy, HeLa, and primary human prostate epithelial cell cultures. Addition of zinc salts 1 h before or 24 h after inoculation with C. trachomatis was found to inhibit growth. Both C. trachomatis serotype D and a lymphogranuloma venereum strain were inhibited by the zinc salts. Although the mechanism of inhibition is not known, the continued presence of the zinc appeared necessary for maximal effect. At the concentrations tested, zinc was not directly toxic to the McCoy cells. These results suggest that the levels of zinc in prostatic secretions may be sufficient to preclude the recovery of chlamydia in the diagnostic laboratory or to inhibit chlamydia from infecting the prostate in vivo.
摘要
锌盐（10⁻⁴和10⁻⁵ M）抑制了沙眼衣原体在 McCoy、HeLa 和原代人前列腺上皮细胞培养物中的包涵体数量。发现在接种沙眼衣原体前1小时或接种后24小时添加锌盐可抑制其生长。沙眼衣原体D血清型和性病性淋巴肉芽肿菌株均受锌盐抑制。虽然抑制机制尚不清楚，但锌的持续存在似乎对最大效应是必要的。在所测试的浓度下，锌对 McCoy 细胞无直接毒性。这些结果表明，前列腺分泌物中的锌水平可能足以阻止衣原体在诊断实验室中的检出，或在体内抑制衣原体感染前列腺。
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