Kostiala A A
Int Arch Allergy Appl Immunol. 1979;60(2):207-15. doi: 10.1159/000232343.
Determination of swelling at an intracutaneous test site in the pinna of the ear of guinea pigs immunized with protein antigens in complete Freund's adjuvant was found to be a more sensitive assay of delayed-type hypersensitivity than the measurement of flank skin erythema and induration. In fact, 100 times less specific antigen was needed to detect 24-hour reactivity in the pinna of the ear. Reactivity early after sensitization (cutaneous basophil hypersensitivity), however, was best revealed as an erythematous lesion of the flank skin 24 h after testing.
在用完全弗氏佐剂免疫的豚鼠耳廓皮内试验部位测定肿胀，被发现是一种比测量胁腹皮肤红斑和硬结更敏感的迟发型超敏反应检测方法。事实上，检测耳廓24小时反应性所需的特异性抗原量要少100倍。然而，致敏后早期的反应性（皮肤嗜碱性粒细胞超敏反应），在检测后24小时，最好表现为胁腹皮肤的红斑性病变。
