• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

大鼠可移植性免疫球蛋白分泌肿瘤。IV. 63个分泌IgE的免疫细胞瘤肿瘤

Transplantable immunoglobulin-secreting tumours in rats. IV. Sixty-three IgE-secreting immunocytoma tumours.

作者信息

Bazin H, Querinjean P, Beckers A, Heremans J F, Dessy F

出版信息

Immunology. 1974 Apr;26(4):713-23.

PMID:4212482
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1423177/
Abstract

The inbred LOU/Wsl rat strain presents a high incidence of spontaneous ileocoecal immunocytoma which secrete monoclonal immunoglobulins. These tumours are transplantable in histocompatible animals and their secreting properties are maintained over many passages. A screening of monoclonal immunoglobulins secreted by 250 such tumours revealed sixty-three proteins which shared class-specific determinants, physicochemical features and biological properties different from those of rat IgM, IgA, IgG1, IgG2a, IgG2b and IgG2c classes, and characteristic of proteins of the IgE class.

摘要

近交系LOU/Wsl大鼠品系出现自发性回盲部免疫细胞瘤的发生率很高，这些肿瘤分泌单克隆免疫球蛋白。这些肿瘤可在组织相容性动物中移植，并且它们的分泌特性在多次传代后仍能保持。对250个此类肿瘤分泌的单克隆免疫球蛋白进行筛选，发现63种蛋白具有共同的类特异性决定簇、物理化学特征和生物学特性，这些特性不同于大鼠IgM、IgA、IgG1、IgG2a、IgG2b和IgG2c类，而是IgE类蛋白的特征。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2dc/1423177/5fce94d22ff0/immunology00327-0045-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2dc/1423177/696f33e44574/immunology00327-0040-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2dc/1423177/cfdf3fb4ef2e/immunology00327-0041-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2dc/1423177/9e8226d19647/immunology00327-0043-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2dc/1423177/9fb804b7062a/immunology00327-0043-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2dc/1423177/5fce94d22ff0/immunology00327-0045-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2dc/1423177/696f33e44574/immunology00327-0040-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2dc/1423177/cfdf3fb4ef2e/immunology00327-0041-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2dc/1423177/9e8226d19647/immunology00327-0043-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2dc/1423177/9fb804b7062a/immunology00327-0043-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2dc/1423177/5fce94d22ff0/immunology00327-0045-a.jpg

相似文献

1
Transplantable immunoglobulin-secreting tumours in rats. IV. Sixty-three IgE-secreting immunocytoma tumours.大鼠可移植性免疫球蛋白分泌肿瘤。IV. 63个分泌IgE的免疫细胞瘤肿瘤
Immunology. 1974 Apr;26(4):713-23.
2
Interaction in vivo of homocytotropic antibodies belonging to two different rat immunoglobulin classes: effect of IgE on the passive cutaneous anaphylactic reaction mediated by IgG a antibodies.属于两种不同大鼠免疫球蛋白类别的亲同种细胞抗体在体内的相互作用：IgE对由IgG a抗体介导的被动皮肤过敏反应的影响。
J Immunol. 1972 Jun;108(6):1637-46.
3
Isolation of IgE from reaginic rat serum.从反应素性大鼠血清中分离免疫球蛋白E
J Immunol. 1974 May;112(5):1909-19.
4
Immunochemical identification of mouse IgE.小鼠免疫球蛋白E的免疫化学鉴定
Immunology. 1972 Oct;23(4):481-91.
5
Specific binding of mouse IgE with rat mast cells.小鼠免疫球蛋白E与大鼠肥大细胞的特异性结合。
J Immunol. 1974 May;112(5):1652-9.
6
Role of TGF-beta 1 on the IgE-dependent anaphylaxis reaction.转化生长因子-β1在IgE依赖的过敏反应中的作用。
J Immunol. 1999 Apr 15;162(8):4960-5.
7
Suppression of skin reactivity in rats bearing IgE or IgG2a immunocytomas.携带IgE或IgG2a免疫细胞瘤的大鼠皮肤反应性的抑制
Aust J Exp Biol Med Sci. 1978 Jun;56(3):333-6. doi: 10.1038/icb.1978.35.
8
[Immunoglobulin secreting tumors in the LOU-Wsl rat: Study of 200 immunocytomas].[LOU-Wsl大鼠中的免疫球蛋白分泌肿瘤：200例免疫细胞瘤的研究]
Ann Immunol (Paris). 1974 Jan;125C(1-2):277-9.
9
The localization of IgE in canine skin: an immunofluorescent study.犬皮肤中IgE的定位：一项免疫荧光研究。
J Immunol. 1973 Feb;110(2):422-30.
10
Preparation of an antiserum specific for rat reagin (rat E?).制备针对大鼠反应素（大鼠E？）的特异性抗血清。
Immunology. 1971 Aug;21(2):383-5.

引用本文的文献

1
An immunologically relevant rodent model demonstrates safety of therapy using a tumour-specific IgE.一种具有免疫相关性的啮齿动物模型证实了使用肿瘤特异性 IgE 进行治疗的安全性。
Allergy. 2018 Dec;73(12):2328-2341. doi: 10.1111/all.13455. Epub 2018 Oct 8.
2
Effects of IL-3 and SCF on Histamine Production Kinetics and Cell Phenotype in Rat Bone Marrow-derived Mast Cells.IL-3 和 SCF 对大鼠骨髓来源肥大细胞组氨酸产生动力学和细胞表型的影响。
Immune Netw. 2010 Feb;10(1):15-25. doi: 10.4110/in.2010.10.1.15. Epub 2010 Feb 28.
3
Our perception of the mast cell from Paul Ehrlich to now.

本文引用的文献

1
PROPERTIES OF RAT ANAPHYLACTIC ANTIBODY.大鼠过敏抗体的特性
J Immunol. 1964 Jun;92:927-33.
2
THE PRODUCTION OF ANAPHYLACTIC ANTIBODY IN THE RAT.大鼠体内过敏抗体的产生
J Immunol. 1964 Jun;92:920-6.
3
Mast cells and anaphylaxis.肥大细胞与过敏反应。
从保罗·埃尔利希到如今我们对肥大细胞的认知。
Eur J Immunol. 2009 Jan;39(1):11-25. doi: 10.1002/eji.200838899.
4
Shuttling of initiating kinase between discrete aggregates of the high affinity receptor for IgE regulates the cellular response.起始激酶在IgE高亲和力受体的离散聚集体之间穿梭，调节细胞反应。
Proc Natl Acad Sci U S A. 1997 Feb 18;94(4):1372-7. doi: 10.1073/pnas.94.4.1372.
5
Differentiation of membrane IgE+ rat B cells into IgE-secreting cells.膜IgE⁺大鼠B细胞向分泌IgE细胞的分化。
Immunology. 1993 Aug;79(4):580-6.
6
Induction of an auto-anti-IgE response in rats. IV. Effects on mast cell degranulation.大鼠自身抗IgE反应的诱导。IV. 对肥大细胞脱颗粒的影响。
Immunology. 1993 Apr;78(4):635-42.
7
Dynamics of signal transduction after aggregation of cell-surface receptors: studies on the type I receptor for IgE.细胞表面受体聚集后信号转导的动力学：对IgE I型受体的研究
Proc Natl Acad Sci U S A. 1994 Apr 12;91(8):3087-91. doi: 10.1073/pnas.91.8.3087.
8
Cellular cytotoxicity and gastrointestinal inflammation in inbred rats: induction with gut organ-specific antigens.近交系大鼠的细胞毒性和胃肠道炎症：肠道器官特异性抗原诱导
Immunology. 1981 Nov;44(3):489-97.
9
IgE antibody-mediated cytotoxicity of rat macrophages against microfilaria of Dipetalonema citeae in vitro.大鼠巨噬细胞IgE抗体介导的体外抗犬恶丝虫微丝蚴细胞毒性作用
Clin Exp Immunol. 1980 Jun;40(3):487-95.
10
Neutrophil-mediated killing of Dipetalonema viteae microfilariae: simultaneous presence of IgE, IgG antibodies and complement is required.中性粒细胞介导的对罗阿丝虫微丝蚴的杀伤作用：需要同时存在IgE、IgG抗体和补体。
Immunology. 1984 Mar;51(3):585-94.
Ann N Y Acad Sci. 1963 Feb 26;103:264-77. doi: 10.1111/j.1749-6632.1963.tb53703.x.
4
Reaginic antibodies and immunity to Nippostrongylus brasiliensis in the rat. II. Some properties of the antibodies and antigens.大鼠体内针对巴西日圆线虫的反应素抗体与免疫性。II. 抗体和抗原的一些特性。
Immunology. 1967 May;12(5):583-97.
5
Reagin-like antibodies in rats infected with the nematode parasite Nippostrongylus brasiliensis.感染巴西日圆线虫这种线虫寄生虫的大鼠体内的类反应素抗体。
Immunology. 1967 Feb;12(2):113-31.
6
Preparation of an antiserum specific for rat reagin (rat E?).制备针对大鼠反应素（大鼠E？）的特异性抗血清。
Immunology. 1971 Aug;21(2):383-5.
7
The significance of circulating IgE. Correlation of amount of circulating reaginic antibody with cutaneous sensitivity in the rat.循环免疫球蛋白E的意义。大鼠循环反应素抗体量与皮肤敏感性的相关性。
Immunology. 1973 Jan;24(1):37-45.
8
Transplantable immunoglobulin-secreting tumours in rats. I. General features of LOU-Ws1 strain rat immunocytomas and their monoclonal proteins.大鼠可移植性免疫球蛋白分泌肿瘤。I. LOU-Ws1品系大鼠免疫细胞瘤及其单克隆蛋白的一般特征。
Int J Cancer. 1972 Nov;10(3):568-80. doi: 10.1002/ijc.2910100316.
9
Transplantable immunoglobulin-secreting tumours in rats. Purification and chemical characterization of four kappa chains from LOU-Wsl rats.大鼠可移植性免疫球蛋白分泌肿瘤。来自LOU-Wsl大鼠的四条κ链的纯化及化学特性分析
Eur J Biochem. 1972 Dec 4;31(2):354-9. doi: 10.1111/j.1432-1033.1972.tb02540.x.
10
IgE multiple myeloma: a report of the third case.IgE 多发性骨髓瘤：第三例报告。
Blood. 1972 Mar;39(3):361-7.