肿瘤细胞的移植动力学
The transplantation kinetics of tumour cells.
作者信息
Porter E H, Hewitt H B, Blake E R
出版信息
Br J Cancer. 1973 Jan;27(1):55-62. doi: 10.1038/bjc.1973.7.
Abstract
The data from a dilution assay can be used not only to form an estimate of the TD50 (or log TD50), but also to throw light on the transplantation kinetics of tumours. Transplantation "by single cells" is the simplest sort of kinetics, and some tumours, of which we have given two examples, will transplant by single cells. Other tumours consistently transplant with anomalous kinetics-i.e. non-single-cell. A sensitive statistical test for single-cell behaviour has been developed, and we give three examples of tumours that clearly fail the test. The mechanism by which these anomalous tumours depart from single-cell behaviour is unknown, but we suggest an approximate statistical analysis for their assay.
摘要
稀释试验的数据不仅可用于估算半数中毒剂量（或半数中毒剂量的对数），还能揭示肿瘤的移植动力学。“单细胞”移植是最简单的动力学类型，我们已给出两个例子的一些肿瘤会通过单细胞进行移植。其他肿瘤始终以异常动力学进行移植，即非单细胞移植。已开发出一种针对单细胞行为的灵敏统计检验方法，我们给出了三个明显未通过该检验的肿瘤例子。这些异常肿瘤偏离单细胞行为的机制尚不清楚，但我们为其检测提出了一种近似的统计分析方法。
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本文引用的文献
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