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1
Effects of time and duration of progesterone administration on mammary tumours induced by 7,12-dimethylbenz(a)anthracene in Sprague-Dawley rats.孕酮给药时间和持续时间对7,12-二甲基苯并(a)蒽诱导的斯普拉格-道利大鼠乳腺肿瘤的影响。
Br J Cancer. 1973 Jan;27(1):63-71. doi: 10.1038/bjc.1973.8.
2
Potent inhibitory effect of a new antiestrogen (RU 16117) on the growth of 7,12-dimethylbenz[a]anthracene-induced rat mammary tumors.一种新型抗雌激素（RU 16117）对7,12-二甲基苯并[a]蒽诱导的大鼠乳腺肿瘤生长的强效抑制作用。
J Natl Cancer Inst. 1977 Mar;58(3):623-8. doi: 10.1093/jnci/58.3.623.
3
An autoradiographic study of the early effects of 7,12-dimethylbenz(a)anthracene and progesterone on DNA synthesis in rat mammary epithelial cells and subsequent tumour development.7,12-二甲基苯并(a)蒽和孕酮对大鼠乳腺上皮细胞DNA合成及随后肿瘤发生的早期影响的放射自显影研究。
Br J Cancer. 1972 Aug;26(4):265-73. doi: 10.1038/bjc.1972.36.
4
Effects of progesterone on mammary carcinogenesis by DMBA applied directly to rat mammae.孕酮对直接涂抹于大鼠乳腺的二甲基苯并蒽诱导的乳腺癌发生的影响。
Br J Cancer. 1979 Aug;40(2):268-73. doi: 10.1038/bjc.1979.175.
5
Progesterone-stimulated growth of mammary carcinomas induced by 7,12-dimethylbenz[a]anthracene in neonatally androgenized rats.孕酮对新生期雄激素化大鼠中由7,12-二甲基苯并[a]蒽诱导的乳腺癌生长的刺激作用。
J Natl Cancer Inst. 1980 Oct;65(4):823-8. doi: 10.1093/jnci/65.4.823.
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Effects of progesterone, ovariectomy and adrenalectomy on mammary tumours induced by 7,12-dimethylbenz(a)anthracene in Sprague-Dawley rats.孕酮、卵巢切除术和肾上腺切除术对7,12-二甲基苯并(a)蒽诱导的斯普拉格-道利大鼠乳腺肿瘤的影响。
Pathology. 1971 Jul;3(3):209-14.
7
Morphology, growth characteristics and oestrogen-binding capacity of DMBA-induced mammary tumours from ovariectomized rats.去卵巢大鼠经二甲基苯并蒽诱导产生的乳腺肿瘤的形态学、生长特性及雌激素结合能力
Br J Cancer. 1977 May;35(5):602-9. doi: 10.1038/bjc.1977.94.
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Effects of hormonal pre-treatment against the induction of mammary tumors by 7,12-dimethylbenz[a]anthracene in rats.激素预处理对7,12-二甲基苯并[a]蒽诱导大鼠乳腺肿瘤的影响。
Z Krebsforsch. 1966;68(3):217-23. doi: 10.1007/BF00524689.
9
Effects of hypothyroidism and progesterone on mammary tumours induced by 7,12-dimethylbenz(a)anthracene in Sprague-Dawley rats.甲状腺功能减退和孕酮对7,12-二甲基苯并(a)蒽诱导的斯普拉格-道利大鼠乳腺肿瘤的影响。
Br J Cancer. 1973 Aug;28(2):161-72. doi: 10.1038/bjc.1973.133.
10
Protection by 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) against mammary tumors and leukemia during prolonged feeding of 7,12-dimethylbenz(a)anthracene to female rats.在向雌性大鼠长期投喂7,12-二甲基苯并(a)蒽期间，1,1,1-三氯-2,2-双(对氯苯基)乙烷（滴滴涕）对乳腺肿瘤和白血病的防护作用。
J Natl Cancer Inst. 1975 Sep;55(3):653-7. doi: 10.1093/jnci/55.3.653.

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Rat Models of Hormone Receptor-Positive Breast Cancer.激素受体阳性乳腺癌的大鼠模型。
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Effects of omega-3 fatty acids on progestin stimulation of invasive properties in breast cancer.ω-3 脂肪酸对孕激素刺激乳腺癌侵袭特性的影响。
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3
Mammary gland neoplasia in long-term rodent studies.长期啮齿动物研究中的乳腺肿瘤形成
Environ Health Perspect. 1996 Sep;104(9):938-67. doi: 10.1289/ehp.96104938.
4
Effect of medroxyprogesterone acetate (MPA) and serum factors on cell proliferation in primary cultures of an MPA-induced mammary adenocarcinoma.醋酸甲羟孕酮（MPA）和血清因子对MPA诱导的乳腺腺癌原代培养细胞增殖的影响。
Breast Cancer Res Treat. 1995 Aug;35(2):173-86. doi: 10.1007/BF00668207.
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Multiple actions of synthetic 'progestins' on the growth of ZR-75-1 human breast cancer cells: an in vitro model for the simultaneous assay of androgen, progestin, estrogen, and glucocorticoid agonistic and antagonistic activities of steroids.合成“孕激素”对ZR-75-1人乳腺癌细胞生长的多种作用：一种用于同时检测类固醇雄激素、孕激素、雌激素和糖皮质激素激动及拮抗活性的体外模型。
Breast Cancer Res Treat. 1991 Jan-Feb;17(3):197-210. doi: 10.1007/BF01806369.
6
Hormone control of total plasminogen activator activity is specific to malignant DMBA-induced rat mammary tumours.激素对总纤溶酶原激活物活性的调控在二甲基苯并蒽诱导的大鼠恶性乳腺肿瘤中具有特异性。
Br J Cancer. 1992 Apr;65(4):578-82. doi: 10.1038/bjc.1992.117.
7
Circadian variations in 32P uptake of DMBA-induced mammary tumour and Walker carcinosarcoma in rats.大鼠中DMBA诱导的乳腺肿瘤和Walker癌肉瘤对32P摄取的昼夜变化。
Br J Cancer. 1976 Jun;33(6):646-54. doi: 10.1038/bjc.1976.102.
8
Effects of progesterone on mammary carcinogenesis by DMBA applied directly to rat mammae.孕酮对直接涂抹于大鼠乳腺的二甲基苯并蒽诱导的乳腺癌发生的影响。
Br J Cancer. 1979 Aug;40(2):268-73. doi: 10.1038/bjc.1979.175.

本文引用的文献

1
THREE TYPES OF MAMMARY TUMOUR INDUCED IN RATS BY FEEDING WITH DMBA.通过给大鼠喂食二甲基苯蒽诱导出的三种乳腺肿瘤。
Br J Cancer. 1964 Sep;13(3):513-20. doi: 10.1038/bjc.1964.58.
2
Inhibition of tumor induction in chemical carcinogenesis in the mammary gland.对乳腺化学致癌过程中肿瘤诱导的抑制作用。
Prog Exp Tumor Res. 1971;14:59-88. doi: 10.1159/000392271.
3
The uptake of progesterone by the uterus of the pregnant rat in vivo and its relationship to cytoplasmic progesterone-binding protein.孕鼠子宫在体内对孕酮的摄取及其与细胞质孕酮结合蛋白的关系。
Endocrinology. 1972 Feb;90(2):507-15. doi: 10.1210/endo-90-2-507.

孕酮给药时间和持续时间对7,12-二甲基苯并(a)蒽诱导的斯普拉格-道利大鼠乳腺肿瘤的影响。

Effects of time and duration of progesterone administration on mammary tumours induced by 7,12-dimethylbenz(a)anthracene in Sprague-Dawley rats.

作者信息

Jabara A G, Toyne P H, Harcourt A G

出版信息

Br J Cancer. 1973 Jan;27(1):63-71. doi: 10.1038/bjc.1973.8.

DOI:10.1038/bjc.1973.8
PMID:4686179
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2008829/
Abstract

A reduction in tumour yield was apparent when progesterone administration was begun 25 days before feeding 7,12-dimethylbenz(a)anthracene (DMBA). This effect was most obvious when the duration of hormone administration was brief. Continuation of progesterone for some time after feeding DMBA caused a progressive diminution of the inhibitory effect, and 135 days of continuous hormone treatment entirely abolished the effects of 25 days pretreatment with the hormone.In contrast, when progesterone injections were begun 2 days after feeding DMBA, there was a trend towards enhancement of tumour yield. Continuous hormone administration appeared more effective than shorter treatment regimens.

摘要

在喂食7,12-二甲基苯并(a)蒽（DMBA）前25天开始给予孕酮时，肿瘤发生率明显降低。当激素给药持续时间较短时，这种效果最为明显。在喂食DMBA后继续给予孕酮一段时间会导致抑制作用逐渐减弱，连续135天的激素治疗完全消除了激素预处理25天的效果。相比之下，在喂食DMBA后2天开始注射孕酮时，肿瘤发生率有增加的趋势。持续激素给药似乎比短期治疗方案更有效。