胰岛素缺乏型糖尿病大鼠外周神经结构和功能的早期可预防变化。
Early and preventable changes of peripheral nerve structure and function in insulin-deficient diabetic rats.
作者信息
Jakobsen J
出版信息
J Neurol Neurosurg Psychiatry. 1979 Jun;42(6):509-18. doi: 10.1136/jnnp.42.6.509.
Abstract
Structure and function of peripheral nerve in early insulin deficient streptozotocin diabetic rat were examined. Quantitative studies of myelinated fibres from electron micrographs showed that the fibre calibre and slope coefficients of regression lines between axon and myelin areas were reduced and quantitation of unmyelinated fibres revealed a 40% reduction in area fraction of smooth endoplasmic reticulum. The difference in conduction velocity between diabetic rats and control rats increased with time just as does the difference in fibre calibre. Insulin treatment was able to prevent the decrease in conduction velocity as well as the reduction in fibre calibre. It is concluded that the early structural axon abnormalities results from the diabetic state and cannot be explained by poor general condition of the animals.
摘要
对早期胰岛素缺乏的链脲佐菌素糖尿病大鼠的外周神经结构和功能进行了检查。对电子显微镜下有髓纤维的定量研究表明，纤维直径以及轴突与髓鞘面积之间回归线的斜率系数均降低，对无髓纤维的定量分析显示，滑面内质网的面积分数降低了40%。糖尿病大鼠与对照大鼠之间的传导速度差异随时间增加，就如同纤维直径差异一样。胰岛素治疗能够预防传导速度的降低以及纤维直径的减小。得出的结论是，早期轴突结构异常是由糖尿病状态导致的，无法用动物的一般健康状况不佳来解释。
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