大鼠和家兔实验性糖尿病中的神经传导速度
Nerve conduction velocity in experimental diabetes in the rat and rabbit.
作者信息
Thomas P K, Jefferys J G, Sharma A K, Bajada S
出版信息
J Neurol Neurosurg Psychiatry. 1981 Mar;44(3):233-8. doi: 10.1136/jnnp.44.3.233.
Abstract
Tibial motor nerve conduction velocity was measured in rats, before and two months after the induction of diabetes with streptozotocin. A second group of diabetic animals was also administered 1% dietary myoinositol supplements. An analysis of variance was performed on these data. Myoinositol supplements had no effect whatsoever. The period of diabetes had a statistically significant and quantitatively marginal effect (a decrease of 2.2 m s-1) on conduction velocity. This is considerably less than in previous reports. The reasons for this are discussed. Tibial motor nerve conduction velocity was also measured in a group of alloxan-diabetic rabbits two months after the induction of diabetes and in an age-matched control group. Conduction velocity was again slightly but significantly less in the diabetic animals.
摘要
在大鼠中，用链脲佐菌素诱导糖尿病之前以及诱导后两个月测量胫神经运动神经传导速度。第二组糖尿病动物也给予1%的膳食肌醇补充剂。对这些数据进行方差分析。肌醇补充剂没有任何效果。糖尿病病程对传导速度有统计学上显著且数量上较小的影响（降低2.2 m s-1）。这比之前的报告中的降幅要小得多。文中讨论了其原因。在一组用四氧嘧啶诱导糖尿病两个月后的兔子以及年龄匹配的对照组中也测量了胫神经运动神经传导速度。糖尿病动物的传导速度再次略有下降，但差异显著。
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