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大鼠和家兔实验性糖尿病中的神经传导速度

Nerve conduction velocity in experimental diabetes in the rat and rabbit.

作者信息

Thomas P K, Jefferys J G, Sharma A K, Bajada S

出版信息

J Neurol Neurosurg Psychiatry. 1981 Mar;44(3):233-8. doi: 10.1136/jnnp.44.3.233.

DOI:10.1136/jnnp.44.3.233
PMID:7229647
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC490898/
Abstract

Tibial motor nerve conduction velocity was measured in rats, before and two months after the induction of diabetes with streptozotocin. A second group of diabetic animals was also administered 1% dietary myoinositol supplements. An analysis of variance was performed on these data. Myoinositol supplements had no effect whatsoever. The period of diabetes had a statistically significant and quantitatively marginal effect (a decrease of 2.2 m s-1) on conduction velocity. This is considerably less than in previous reports. The reasons for this are discussed. Tibial motor nerve conduction velocity was also measured in a group of alloxan-diabetic rabbits two months after the induction of diabetes and in an age-matched control group. Conduction velocity was again slightly but significantly less in the diabetic animals.

摘要

在大鼠中,用链脲佐菌素诱导糖尿病之前以及诱导后两个月测量胫神经运动神经传导速度。第二组糖尿病动物也给予1%的膳食肌醇补充剂。对这些数据进行方差分析。肌醇补充剂没有任何效果。糖尿病病程对传导速度有统计学上显著且数量上较小的影响(降低2.2 m s-1)。这比之前的报告中的降幅要小得多。文中讨论了其原因。在一组用四氧嘧啶诱导糖尿病两个月后的兔子以及年龄匹配的对照组中也测量了胫神经运动神经传导速度。糖尿病动物的传导速度再次略有下降,但差异显著。

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本文引用的文献

1
NERVE CONDUCTION CHANGES IN EXPERIMENTAL DIABETES.实验性糖尿病中的神经传导变化
J Clin Invest. 1964 Dec;43(12):2353-8. doi: 10.1172/JCI105109.
2
Age changes in conduction velocity, refractory period, number of fibers, connective tissue space and blood vessels in sciatic nerve of rats.大鼠坐骨神经传导速度、不应期、纤维数量、结缔组织间隙及血管的年龄变化
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Changes with age in the peripheral nerves of the rat. An ultrastructural study.大鼠外周神经随年龄的变化。一项超微结构研究。
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Diabetic neuropathy: influence of age, sex, metabolic control, and duration of diabetes on motor conduction velocity.糖尿病性神经病变:年龄、性别、代谢控制及糖尿病病程对运动传导速度的影响
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Polyol accumulations in nervous tissue of rats with experimental diabetes and galactosaemia.实验性糖尿病和半乳糖血症大鼠神经组织中的多元醇蓄积
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Properties of isolated nerve fibres from alloxanized rats.来自四氧嘧啶处理大鼠的分离神经纤维的特性。
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Serial in vivo determination of motor conduction velocity in tails of allaxanized non-diabetic and diabetic rats.对四氧嘧啶致糖尿病和非糖尿病大鼠尾部运动传导速度进行连续活体测定。
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Phosphoinositide interconversion: a model for control of Na + and K + permeability in the nerve axon membrane.磷酸肌醇相互转化:神经轴突膜中钠钾通透性控制的一种模型
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