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早期实验性糖尿病中的轴突萎缩。I. 对横切神经的研究。

Axonal dwindling in early experimental diabetes. I. A study of cross sectioned nerves.

作者信息

Jakobsen J

出版信息

Diabetologia. 1976 Dec;12(6):539-46. doi: 10.1007/BF01220629.

DOI:10.1007/BF01220629
PMID:137157
Abstract

A diminution of the cross sectional area of myelinated fibres in the common peroneal nerve was observed in rats four weeks after the induction of diabetes with streptozotocin. Small fibres were affected more than larger ones and the axon reduction was twice that of the myelin sheath. The fibre diminution and the decreased axon/myelin ratio may explain the slowing of nerve conduction in experimental diabetes.

摘要

用链脲佐菌素诱导大鼠患糖尿病四周后，观察到其腓总神经中有髓纤维的横截面积减小。小纤维比大纤维受影响更大，轴突减少量是髓鞘的两倍。纤维减少以及轴突/髓鞘比率降低可能解释了实验性糖尿病中神经传导的减慢。

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1
Axonal dwindling in early experimental diabetes. I. A study of cross sectioned nerves.早期实验性糖尿病中的轴突萎缩。I. 对横切神经的研究。
Diabetologia. 1976 Dec;12(6):539-46. doi: 10.1007/BF01220629.
2
Axonal dwindling in early experimental diabetes. II. A study of isolated nerve fibres.早期实验性糖尿病中的轴突萎缩。II. 对分离神经纤维的研究。
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Peripheral nerve axonal dwindling with concomitant myelin sheath hypertrophy in experimentally induced diabetes.实验性诱导糖尿病中周围神经轴突萎缩伴髓鞘肥大。
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Peripheral nerve fiber size in experimental diabetes.实验性糖尿病中的周围神经纤维大小
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[Experimental diabetic neuropathy. Morphometric studies on the rat N. suralis in short-term streptozotocin-induced diabetes].
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本文引用的文献

1
A theory of the effects of fibre size in medullated nerve.有髓神经中纤维大小影响的理论。
J Physiol. 1951 Sep;115(1):101-22. doi: 10.1113/jphysiol.1951.sp004655.
2
NERVE CONDUCTION CHANGES IN EXPERIMENTAL DIABETES.实验性糖尿病中的神经传导变化
J Clin Invest. 1964 Dec;43(12):2353-8. doi: 10.1172/JCI105109.
3
PATHOLOGICAL OBSERVATIONS ON SIX CASES OF DIABETIC NEUROPATHY.6例糖尿病性神经病变的病理学观察
慢性糖尿病和高血压与腓肠神经形态计量学的关系：一项实验研究。
Diabetol Metab Syndr. 2015 Feb 15;7:9. doi: 10.1186/s13098-015-0005-8. eCollection 2015.
4
Myosin Va but Not nNOSα is Significantly Reduced in Jejunal Musculomotor Nerve Terminals in Diabetes Mellitus.肌球蛋白 Va，但不是 nNOSα，在糖尿病中显著减少在空肠运动神经末梢。
Front Med (Lausanne). 2014 Jun 20;1:17. doi: 10.3389/fmed.2014.00017. eCollection 2014.
5
Axonal transport: how high microtubule density can compensate for boundary effects in small-caliber axons.轴突运输：高微管密度如何在小直径轴突中补偿边界效应。
Biophys J. 2014 Feb 18;106(4):813-23. doi: 10.1016/j.bpj.2013.12.047.
6
Therapeutic effects of fenofibrate on diabetic peripheral neuropathy by improving endothelial and neural survival in db/db mice.非诺贝特通过改善db/db小鼠的内皮细胞和神经存活对糖尿病周围神经病变的治疗作用。
PLoS One. 2014 Jan 2;9(1):e83204. doi: 10.1371/journal.pone.0083204. eCollection 2014.
7
Peripheral neuropathy in rats exposed to dichloroacetate.暴露于二氯乙酸的大鼠的周围神经病变
J Neuropathol Exp Neurol. 2009 Sep;68(9):985-93. doi: 10.1097/NEN.0b013e3181b40217.
8
The role of the p75 neurotrophin receptor in the morphology of dorsal root ganglion cells in streptozotocin diabetic mice: effects of sciatic nerve crush.p75神经营养因子受体在链脲佐菌素诱导的糖尿病小鼠背根神经节细胞形态中的作用：坐骨神经挤压的影响
Diabetologia. 2004 Sep;47(9):1502-10. doi: 10.1007/s00125-004-1504-6. Epub 2004 Sep 9.
9
Future treatments for diabetic neuropathy: clues from experimental neuropathy.糖尿病性神经病变的未来治疗方法：来自实验性神经病变的线索
Curr Diab Rep. 2002 Dec;2(6):482-8. doi: 10.1007/s11892-002-0117-z.
10
Structural abnormalities do not explain the early functional abnormalities in the peripheral nerves of the streptozotocin diabetic rat.结构异常并不能解释链脲佐菌素诱导的糖尿病大鼠外周神经早期功能异常的原因。
J Anat. 1999 Oct;195 ( Pt 3)(Pt 3):419-27. doi: 10.1046/j.1469-7580.1999.19530419.x.
Brain. 1964 Jun;87:201-14. doi: 10.1093/brain/87.2.201.
4
Diabetic neuropathy: influence of age, sex, metabolic control, and duration of diabetes on motor conduction velocity.糖尿病性神经病变：年龄、性别、代谢控制及糖尿病病程对运动传导速度的影响
Neurology. 1967 Oct;17(10):972-80. doi: 10.1212/wnl.17.10.972.
5
Peripheral neuropathy in the alloxan-diabetic rat.四氧嘧啶糖尿病大鼠的周围神经病变
J Physiol. 1967 Apr;189(2):49P-50P.
6
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7
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8
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9
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10
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J Comp Neurol. 1973 Jan 15;147(2):255-66. doi: 10.1002/cne.901470207.