尿中3-甲基组氨酸排泄量在指示肌肉蛋白分解方面的临床实用性。
Clinical usefulness of urinary 3-methylhistidine excretion in indicating muscle protein breakdown.
作者信息
Elia M, Carter A, Bacon S, Winearls C G, Smith R
出版信息
Br Med J (Clin Res Ed). 1981 Jan 31;282(6261):351-4. doi: 10.1136/bmj.282.6261.351.
Abstract
Urinary excretion of the post-translationally modified amino-acid 3-methylhistidine, derived from the contractile proteins actin and myosin, was measured in patients with conditions associated with nitrogen loss. The ratio of 3-methylhistidine:creatinine excretion, a measure of the fractional catabolic rate of myofibrillar protein was increased in severe injury, thyrotoxicosis, neoplastic disease, prednisolone administration, and sometimes Duchenne muscular dystrophy. In myxoedema, osteomalacia, and hypothermia the ratio was decreased; and starvation, elective operations, and rheumatoid arthritis had little effect. Provided that the diet is meat free, measurement of urinary 3-methylhistidine may provide useful information on the cause of protein loss.
摘要
在患有与氮流失相关疾病的患者中，测量了源自收缩蛋白肌动蛋白和肌球蛋白的翻译后修饰氨基酸3 - 甲基组氨酸的尿排泄量。在严重损伤、甲状腺毒症、肿瘤性疾病、使用泼尼松龙以及有时在杜氏肌营养不良症中，3 - 甲基组氨酸与肌酐排泄的比率（一种肌原纤维蛋白分解代谢率的指标）会升高。在黏液性水肿、骨软化症和体温过低时，该比率会降低；饥饿、择期手术和类风湿性关节炎对此影响不大。如果饮食不含肉类，测量尿中3 - 甲基组氨酸可能会为蛋白质流失的原因提供有用信息。
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