通过尿中3-甲基组氨酸排泄量测定杜氏肌营养不良症中肌原纤维蛋白分解代谢增加。
Increased myofibrillar protein catabolism in Duchenne muscular dystrophy measured by 3-methylhistidine excretion in the urine.
作者信息
McKeran R O, Halliday D, Purkiss P
出版信息
J Neurol Neurosurg Psychiatry. 1977 Oct;40(10):979-81. doi: 10.1136/jnnp.40.10.979.
Abstract
Myofibrillar protein catabolic rate was calculated in seven patients with Duchenne muscular dystrophy from the amount of 3-methylhistidine excreted in the urine, and found to be over three times that found in a control series when expresses as the percentage of myofibrillar protein catabolised per day. It is suggested that measurement of myofibrillar protein catabolic rate may add a useful parameter in the study of muscle disorders.
摘要
通过测定7例杜氏肌营养不良症患者尿中3 - 甲基组氨酸的排泄量，计算出肌原纤维蛋白分解代谢率。当以每日分解代谢的肌原纤维蛋白百分比表示时，发现该代谢率是对照组的三倍多。有人提出，测定肌原纤维蛋白分解代谢率可能为肌肉疾病的研究增加一个有用的参数。
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