Increased myofibrillar protein catabolism in duchenne muscular dystrophy measured by 3-methylhistidine excretion in the urine.
作者信息
Mussini E, Cornelio F, Colombo L, De Ponte G, Giudici G, Cotellessa L, Marcucci F
出版信息
Muscle Nerve. 1984 Jun;7(5):388-91. doi: 10.1002/mus.880070508.
PMID:6738577
Abstract
Myofibrillar protein catabolic rate was calculated in 50 young patients with Duchenne muscular dystrophy from the amount of 3-methylhistidine excreted in the urine, and was found to be about seven times that of a control series, expressed as the percentage of myofibrillar protein catabolized per day. This wastage of myofibrillar protein is a consequence of Duchenne muscular dystrophy and inhibition of protein degradation appears to be one possible approach in the treatment of this disease.
摘要
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Increased myofibrillar protein catabolism in duchenne muscular dystrophy measured by 3-methylhistidine excretion in the urine.
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