胍法辛与可乐定作为抗高血压药物的比较。
Comparison of guanfacine and clonidine as antihypertensive agents.
作者信息
Jäättelä A
出版信息
Br J Clin Pharmacol. 1980;10 Suppl 1(Suppl 1):67S-70S. doi: 10.1111/j.1365-2125.1980.tb04908.x.
Abstract
- The antihypertensive effects and side-effects of guanfacine and clonidine were compared in a single-blind, cross-over study. 2. The study consisted of two active treatment periods of 6 weeks each, which were both preceded by a 2 weeks placebo period. Thirty ambulatory, hypertensive patients (blood pressure WHO severity grades I-II) were admitted to the study. The results are based on the 24 patients who completed the study. 3. The optimal daily dose of guanfacine was in over half of the patients 3-4 mg, and of clonidine correspondingly 0.3-0.45 mg. A similar and statistically significant decrease in blood pressure was achieved with both drugs. 4. The most common side-effects with both drugs were tiredness and dryness of the mouth.
摘要
- 在一项单盲交叉研究中比较了胍法辛和可乐定的降压效果及副作用。2. 该研究包括两个各为期6周的积极治疗期，每个治疗期之前均有一个为期2周的安慰剂期。30名非卧床高血压患者（世界卫生组织血压严重程度分级为I-II级）被纳入该研究。结果基于完成研究的24名患者。3. 超过半数患者的胍法辛最佳日剂量为3 - 4毫克，可乐定相应为0.3 - 0.45毫克。两种药物均使血压出现类似且具有统计学意义的下降。4. 两种药物最常见的副作用是疲倦和口干。
相似文献
1
Comparison of guanfacine and clonidine as antihypertensive agents.胍法辛与可乐定作为抗高血压药物的比较。
Br J Clin Pharmacol. 1980;10 Suppl 1(Suppl 1):67S-70S. doi: 10.1111/j.1365-2125.1980.tb04908.x.
2
Antihypertensive effect of guanfacine: a double-blind cross-over trial compared with clonidine.胍法辛的降压作用：与可乐定比较的双盲交叉试验
Br J Clin Pharmacol. 1980;10 Suppl 1(Suppl 1):49S-53S. doi: 10.1111/j.1365-2125.1980.tb04904.x.
3
Clinical experience with guanfacine in long-term treatment of hypertension. Part II: adverse reactions to guanfacine.胍法辛长期治疗高血压的临床经验。第二部分：胍法辛的不良反应。
Br J Clin Pharmacol. 1980;10 Suppl 1(Suppl 1):157S-164S. doi: 10.1111/j.1365-2125.1980.tb04924.x.
4
[A new antihypertensive agent used in a clinical setting].[一种用于临床环境的新型抗高血压药物]
Med Klin. 1980 Sep 12;75(19):688-92.
5
Hypotensive effect of guanfacine in essential hypertension: a comparison with clonidine.胍法辛对原发性高血压的降压作用：与可乐定的比较。
Br J Clin Pharmacol. 1980;10 Suppl 1(Suppl 1):81S-82S. doi: 10.1111/j.1365-2125.1980.tb04910.x.
6
Comparative study of two antihypertensive agents: guanfacine and guanethidine.两种抗高血压药物：胍法辛和胍乙啶的对比研究。
Br J Clin Pharmacol. 1980;10 Suppl 1(Suppl 1):85S-87S. doi: 10.1111/j.1365-2125.1980.tb04912.x.
7
Evaluation of guanfacine and clonidine in essential hypertension: a single-blind crossover study.
Med J Aust. 1980 Oct 4;2(7):395-6. doi: 10.5694/j.1326-5377.1980.tb131883.x.
8
Effects of single and multiple doses of guanfacine in essential hypertension.单剂量和多剂量胍法辛对原发性高血压的影响。
Clin Pharmacol Ther. 1980 Dec;28(6):715-21. doi: 10.1038/clpt.1980.226.
9
Comparison of antihypertensive activity and tolerability of guanfacine and methyldopa.胍法辛与甲基多巴的降压活性及耐受性比较。
Int J Clin Pharmacol Res. 1983;3(1):35-9.
10
Clonidine and guanfacine in hypertension.可乐定与胍法辛治疗高血压
Clin Pharmacol Ther. 1985 Mar;37(3):271-6. doi: 10.1038/clpt.1985.39.
引用本文的文献
1
Hypertensive Crisis in a Pediatric Patient Experiencing Clonidine Withdrawal.一名小儿患者可乐定撤药时出现高血压危象。
Case Rep Pediatr. 2022 Mar 22;2022:9005063. doi: 10.1155/2022/9005063. eCollection 2022.
本文引用的文献
1
Clonidine hydrochloride in the treatment of hypertension.盐酸可乐定治疗高血压。
Am J Cardiol. 1971 Jul;28(1):67-73. doi: 10.1016/0002-9149(71)90036-1.
2
Clonidine (Catapres): a new antihypertensive agent.
Curr Ther Res Clin Exp. 1970 Jan;12(1):10-8.
3
Effects of clonidine withdrawal: possible mechanisms and suggestions for management.可乐定撤药的影响：可能机制及处理建议
Br Med J. 1973 Apr 28;2(5860):209-11. doi: 10.1136/bmj.2.5860.209.
4
Evidence for an alpha-sympathomimetic component in the effects of catapresan on vasomotor centres: antagonism by piperoxane.可乐宁对血管运动中枢作用中α-拟交感神经成分的证据：哌氧环烷的拮抗作用。
Eur J Pharmacol. 1971;14(1):98-100. doi: 10.1016/0014-2999(71)90130-0.
Zotero 插件