Viadana E, Bross I D, Pickren J W
Br J Cancer. 1973 Apr;27(4):336-40. doi: 10.1038/bjc.1973.40.
Autopsy records based on 647 primary carcinomata of the breast provided the data to describe a few possible routes of dissemination of cancer of the breast. Calculations were made to test whether the hypothesis of a multistep dissemination of the tumour from the primary site was likely. A multistep dissemination means that the presence of metastases at peripheral sites is influenced by the presence of the tumour in 3 organs, i.e. lungs, liver and bones, very often seeded by the primary cancer.Several interpretations are discussed, with emphasis on those findings which could be explained in terms of a haematic route of dissemination or in terms of an anatomical proximity.
基于647例原发性乳腺癌尸检记录的数据,描述了乳腺癌可能的几种扩散途径。进行了相关计算,以检验肿瘤从原发部位多步骤扩散这一假说的可能性。多步骤扩散是指外周部位转移灶的出现受三个器官(即肺、肝和骨)肿瘤存在的影响,这些器官常常由原发性癌播散种植。讨论了几种解释,重点是那些可以用血液扩散途径或解剖学邻近关系来解释的发现。