Iwai N, Ogita S, Kida M, Nishioka B, Fujita Y, Majima S
Jpn J Surg. 1979 Sep;9(3):234-40. doi: 10.1007/BF02469426.
Anorectal manometric studies were performed on nine patients with Hirschsprung's disease and ten patients with idiopathic megacolon for the purpose of differentiation, comparing with those of the normal subjects. The anorectal reflex was absent in all nine of the patients with Hirschsprung's disease while in all of ten patients with idiopathic megacolon rectal distension produced a relaxation in the anal canal like that of the normal subjects. Manometric studies proved to be a reliable and non-invasive technique for the diagnosis of Hirschsprung's disease and were of particular value as simple screening tests in patients with a clinical suggestion of this disease. The manometric studies of the patients with Hirschsprung's disease or idiopathic megacolon in the present series also demonstrated that the pronounced internal sphincter contraction combined with a total absence of reflex relaxation or an inadequate response of the sphincter to rectal distension might be responsible for the obstructive symptoms in these diseases.
为了进行鉴别诊断，对9例先天性巨结肠患者和10例特发性巨结肠患者进行了肛门直肠测压研究，并与正常受试者的测压结果进行比较。9例先天性巨结肠患者均无肛门直肠反射，而10例特发性巨结肠患者直肠扩张时肛管均出现与正常受试者类似的松弛。测压研究被证明是诊断先天性巨结肠的一种可靠且非侵入性的技术，作为对有该病临床提示的患者进行简单筛查试验具有特殊价值。本系列中先天性巨结肠或特发性巨结肠患者的测压研究还表明，内括约肌明显收缩，同时完全缺乏反射性松弛或括约肌对直肠扩张反应不足，可能是这些疾病出现梗阻症状的原因。
