Gressner A M, Schulz W, Greiling H
Mech Ageing Dev. 1979 Jul;10(6):445-50. doi: 10.1016/0047-6374(79)90023-x.
The synthesis of glycosaminoglycans (GAG) was studied in liver slices from postnatal (9 days), young (140 days), adult (490 days) and senescent (940 days) rats. It was found that the rate of synthesis was highest in postnatal rat liver and decreased to about half in young rats with no further reduction in adult and senescent age groups. The specific radioactivity of the precursors of GAG synthesis did not change with age. The synthesis pattern of specific types of GAG in postnatal liver was characterized by a significant higher percentage of chondroitin sulfate and hyaluronic acid. In the following age classes the profile of specific GAG synthesis did not change significantly (heparin sulfate: chondroitin sulfate" hyaluronic acid: "keratin sulfate" = 84%:8.3%:1.5%:1.6%).
对出生后（9天）、幼年（140天）、成年（490天）和衰老（940天）大鼠的肝切片中糖胺聚糖（GAG）的合成进行了研究。结果发现，出生后大鼠肝脏的合成速率最高，幼年大鼠降低至约一半，成年和衰老年龄组则没有进一步降低。GAG合成前体的比放射性不随年龄变化。出生后肝脏中特定类型GAG的合成模式表现为硫酸软骨素和透明质酸的百分比显著更高。在随后的年龄组中，特定GAG合成的概况没有显著变化（硫酸乙酰肝素：硫酸软骨素：透明质酸：硫酸角质素 = 84%：8.3%：1.5%：1.6%）。
