Emmerson B T, Thompson L, Mitchell K
Nephron. 1979;23 Suppl 1:38-40. doi: 10.1159/000181666.
Doses of 20, 40, 60 and 80 mg of the indanone diuretic MK-196 and 40 mg of frusemide were administered in random order to 5 healthy volunteers in a stable metabolic state, on the same day for 5 consecutive weeks. Diuresis, natriuresis and kaluresis increased with increasing doses, the natriuresis lasting for about 12 h and the kaluresis for about 24 h. Uricosuria increased with increasing doses of MK-196 and lasted for about 6 h. The uricosuria was followed by urate retention, so that there was little net change in the renal excretion of urate. Significant weight loss occurred, so that there was probably some associated plasma volume contraction, which would promote urate retention. By contrast, frusemide caused a reduction in renal excretion of urate at all times.
将20毫克、40毫克、60毫克和80毫克茚满二酮利尿剂MK - 196以及40毫克速尿以随机顺序给予5名处于稳定代谢状态的健康志愿者，在同一天连续5周给药。随着剂量增加，利尿、利钠和利钾作用增强，利钠作用持续约12小时，利钾作用持续约24小时。随着MK - 196剂量增加，尿酸尿增加，持续约6小时。尿酸尿之后出现尿酸潴留，因此尿酸的肾脏排泄几乎没有净变化。体重显著减轻，所以可能存在一些相关的血浆容量收缩，这会促进尿酸潴留。相比之下，速尿在所有时间都会导致尿酸肾脏排泄减少。
