Fedrick J
Br Med J. 1973 May 26;2(5864):442-8. doi: 10.1136/bmj.2.5864.442.
The files of the Oxford Record Linkage Study were used to identify 223 infants delivered to 168 epileptic women as the result of 218 pregnancies. There were six stillbirths, two of which were grossly malformed. It was shown that the population of epileptic mothers differed significantly from the total reproducing population in respect of social class. Each pregnancy resulting in a livebirth was therefore matched exactly for social class, civil status, maternal age, parity, hospital, and year of delivery with three control deliveries resulting in livebirths. The defects noted at birth were abstracted from the Record Linkage files, and any subsequent hospital admissions or deaths of the children were also abstracted.There were highly significant excesses of congenital abnormalities among the infants born to epileptic mothers (13.8% of livebirths had some degree of defect of congenital origin compared with 5.6% of controls, P <0.0005). It was shown that neither the frequency with which the mother had fits nor the length of time she had had the epilepsy seemed to bear any relation to the frequency of defects in the offspring-with the exception of the two mothers who developed epilepsy in the first
牛津记录链接研究的档案被用于识别168名癫痫女性在218次怀孕后所分娩的223名婴儿。有6例死产，其中2例严重畸形。结果表明，癫痫母亲群体在社会阶层方面与整个生育群体存在显著差异。因此，每一例导致活产的怀孕都在社会阶层、婚姻状况、母亲年龄、产次、医院和分娩年份等方面与三例导致活产的对照分娩进行了精确匹配。出生时记录的缺陷从记录链接档案中提取，儿童随后的任何住院情况或死亡情况也被提取。癫痫母亲所生婴儿中先天性异常的比例显著过高（13.8%的活产婴儿有某种程度的先天性缺陷，而对照组为5.6%，P<0.0005）。结果表明，母亲癫痫发作的频率和患癫痫的时间长短似乎都与后代缺陷的频率无关——除了两名在首次……时患癫痫的母亲。
