手术对癌症患者淋巴细胞转化的影响。
The effects of surgery on lymphocyte transformation in patients with cancer.
作者信息
Watkins S M
出版信息
Clin Exp Immunol. 1973 May;14(1):69-76.
Abstract
Lymphocyte response to phytohaemagglutinin (PHA) was subnormal in twenty-two out of thirty-six patients with various types of non-lymphoid malignancy. After apparently successful surgery, lymphocyte response improved significantly in most of those in whom it had been previously impaired; it remained markedly subnormal in only two patients, one of whom subsequently died of metastases. This finding indicates that depressed cell-mediated immunity in patients with cancer is the result of the malignant disease. Failure of the PHA response to revert to normal post-operatively may indicate a poor prognosis.
摘要
36例各种类型非淋巴系统恶性肿瘤患者中，22例对植物血凝素（PHA）的淋巴细胞反应低于正常水平。在进行了看似成功的手术后，大多数术前淋巴细胞反应受损的患者反应明显改善；仅2例仍明显低于正常水平，其中1例随后死于转移。这一发现表明，癌症患者细胞介导免疫功能低下是恶性疾病所致。术后PHA反应未能恢复正常可能预示预后不良。
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