咖啡因和异丙肾上腺素对哺乳动物心室肌的影响。
Effects of caffeine and isoprenaline on mammalian ventricular muscle.
作者信息
Clark A, Olson C B
出版信息
Br J Pharmacol. 1973 Jan;47(1):1-11. doi: 10.1111/j.1476-5381.1973.tb08153.x.
Abstract
- Caffeine, 0.6-20.0 mM, altered the duration of the action potential recorded from kitten papillary muscles; low concentrations shortened and high concentrations prolonged the action potential.2. Caffeine, 20 mM, prolonged the action potential by delaying the final phase of repolarization.3. Caffeine, 2.0-20.0 mM increased the tension developed and the duration of the isometric contraction.4. When large stimulating electrodes were used, all concentrations of caffeine increased the duration of the action potential; this effect was probably due to the interactions of caffeine and released endogenous catecholamines.5. Concentrations of caffeine and isoprenaline, which separately caused little change in the duration of the action potential, greatly prolonged the action potential when used together.6. The effects of caffeine may be due to an increase in membrane calcium current in addition to an action on intracellular calcium stores.
摘要
浓度为0.6 - 20.0毫摩尔的咖啡因改变了从小猫乳头肌记录到的动作电位的持续时间；低浓度使其缩短，高浓度使其延长。
20毫摩尔的咖啡因通过延迟复极化的最后阶段来延长动作电位。
2.0 - 20.0毫摩尔的咖啡因增加了张力的产生以及等长收缩的持续时间。
当使用大型刺激电极时，所有浓度的咖啡因都会增加动作电位的持续时间；这种效应可能是由于咖啡因与释放的内源性儿茶酚胺相互作用所致。
单独使用时对动作电位持续时间几乎没有影响的咖啡因和异丙肾上腺素浓度，一起使用时会大大延长动作电位。
咖啡因的作用可能不仅是对细胞内钙储存起作用，还可能是由于膜钙电流增加。
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本文引用的文献
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