Duignan N M, Andrews J, Williams J D
Br Med J. 1973 Jul 14;3(5871):75-8. doi: 10.1136/bmj.3.5871.75.
The placental transmission of lincomycin was studied in 60 patients in late pregnancy. A peak maternal blood level of 12.5 mug/ml was recorded 45 minutes after injection, and detectable levels were still present up to 42 hours after a single injection. A peak cord blood level of 2.7 mug/ml was recorded 55 minutes after injection; cord blood levels were about a quarter of the maternal blood levels, and in most cases no levels were detectable 24 hours after a single injection. The passage of lincomycin into and out of the liquor was slower and more variable, but some hours after injection the liquor levels were always higher than the maternal or cord blood levels, and detectable levels were still present in the liquor 52 hours after a single injection. Repeated injections did not lead to any significant accumulation of lincomycin. The only side effect was a possible case of neuromuscular block in a mother delivered by caesarean section. No infant was adversely affected.
对60例妊娠晚期患者进行了林可霉素的胎盘转运研究。注射后45分钟，母体血药浓度峰值记录为12.5微克/毫升，单次注射后长达42小时仍可检测到血药浓度。注射后55分钟，脐血药浓度峰值记录为2.7微克/毫升；脐血药浓度约为母体血药浓度的四分之一，在大多数情况下，单次注射24小时后无法检测到血药浓度。林可霉素进出脑脊液的过程较慢且变异性较大，但注射数小时后，脑脊液中的药物浓度始终高于母体或脐血中的药物浓度，单次注射52小时后脑脊液中仍可检测到药物浓度。重复注射未导致林可霉素有任何显著蓄积。唯一的副作用是1例剖宫产产妇可能出现神经肌肉阻滞。没有婴儿受到不良影响。
