长春碱对正常人中性粒细胞趋化反应性的影响。
Effect of vinblastine on the chemotactic responsiveness of normal human neutrophils.
作者信息
Edelson P J, Fudenberg H F
出版信息
Infect Immun. 1973 Jul;8(1):127-9. doi: 10.1128/iai.8.1.127-129.1973.
Abstract
The effect of vinblastine on the mobility of human neutrophils was studied. Chemotactic responsiveness was decreased by approximately 80 to 95%, as measured in Boyden chambers, whereas random mobility, as measured in glass capillary tubes, was approximately doubled. Chemotactic responsiveness could be partially restored after dialysis of the treated cells, which is not compatible with an action of vinblastine on microtubules. The possibility is considered that this observation is an additional example of the effect of several microtubular binding agents on phenomena mediated at the phagocytic surface.
摘要
研究了长春花碱对人中性粒细胞运动性的影响。用博伊登小室测量，趋化反应性降低了约80%至95%，而用玻璃毛细管测量的随机运动性则增加了约一倍。经处理的细胞透析后，趋化反应性可部分恢复，这与长春花碱对微管的作用不相符。有人认为，这一观察结果是几种微管结合剂对吞噬表面介导现象产生影响的又一个例子。
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