• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

乙醛对牛脑和牛肾丙酮酸脱氢酶复合体的抑制作用。

Inhibition by acetaldehyde of the pyruvate dehydrogenase complex from ox brain and ox kidney.

作者信息

Blass J P, Lewis C A

出版信息

Biochem J. 1973 Feb;131(2):415-6. doi: 10.1042/bj1310415.

DOI:10.1042/bj1310415
PMID:4722444
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1177482/
Abstract

Low concentrations of acetaldehyde, similar to those that can occur in the brain of ethanol-treated animals, effectively inhibit the pyruvate dehydrogenase complex purified from ox brain or from ox kidney, although the precise mechanism of this inhibition remains to be defined.

摘要

低浓度的乙醛，类似于在经乙醇处理的动物大脑中可能出现的浓度，能有效抑制从牛脑或牛肾中纯化得到的丙酮酸脱氢酶复合体，尽管这种抑制的确切机制仍有待确定。

相似文献

1
Inhibition by acetaldehyde of the pyruvate dehydrogenase complex from ox brain and ox kidney.乙醛对牛脑和牛肾丙酮酸脱氢酶复合体的抑制作用。
Biochem J. 1973 Feb;131(2):415-6. doi: 10.1042/bj1310415.
2
Kinetic properties of the partially purified pyruvate dehydrogenase complex of ox brain.牛脑部分纯化丙酮酸脱氢酶复合体的动力学特性
Biochem J. 1973 Jan;131(1):31-7. doi: 10.1042/bj1310031.
3
Impairment of pyruvate dehydrogenase activity by acetaldehyde.乙醛对丙酮酸脱氢酶活性的损害。
Alcohol. 2001 Aug;25(1):1-8. doi: 10.1016/s0741-8329(01)00156-2.
4
Kinetic studies of the inhibitory effect of acetaldehyde and D(-)acetoin on the pyruvate dehydrogenase complex from pig heart.乙醛和D(-)-乙偶姻对猪心脏丙酮酸脱氢酶复合体抑制作用的动力学研究。
Acta Biochim Biophys Acad Sci Hung. 1978;13(3):143-52.
5
Function of the nonidentical subunits of mammalian pyruvate dehydrogenase.哺乳动物丙酮酸脱氢酶不同亚基的功能。
Biochem Biophys Res Commun. 1972 Aug 21;48(4):840-6. doi: 10.1016/0006-291x(72)90684-5.
6
[Coenzyme-binding sites of the brain pyruvate dehydrogenase complex].[脑丙酮酸脱氢酶复合体的辅酶结合位点]
Ukr Biokhim Zh (1978). 1992 May-Jun;64(3):46-51.
7
The elementary reactions of the pig heart pyruvate dehydrogenase complex. A study of the inhibition by phosphorylation.猪心脏丙酮酸脱氢酶复合体的基本反应。磷酸化抑制作用的研究。
Biochem J. 1976 Jul 1;157(1):41-67. doi: 10.1042/bj1570041.
8
Influence of phenylpyruvate on the interconversion of pyruvate dehydrogenase complex from mammalian brain and kidney.苯丙酮酸对哺乳动物脑和肾中丙酮酸脱氢酶复合体相互转化的影响。
FEBS Lett. 1974 Jul 1;43(1):116-8. doi: 10.1016/0014-5793(74)81119-1.
9
Low immunogenicity of the common lipoamide dehydrogenase subunit (E3) of mammalian pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multienzyme complexes.哺乳动物丙酮酸脱氢酶和2-氧代戊二酸脱氢酶多酶复合物常见的硫辛酰胺脱氢酶亚基（E3）的低免疫原性。
Biochem J. 1985 Mar 1;226(2):509-17. doi: 10.1042/bj2260509.
10
[The effect of phosphorylation on oxidative and CoA- and NAD+-independent turnover of pyruvate by pyruvate dehydrogenase complex in the brain].[磷酸化对大脑中丙酮酸脱氢酶复合物介导的丙酮酸氧化及不依赖辅酶A和烟酰胺腺嘌呤二核苷酸的周转的影响]
Ukr Biokhim Zh (1978). 1990 Sep-Oct;62(5):55-61.

引用本文的文献

1
Inhibition effects of furfural on alcohol dehydrogenase, aldehyde dehydrogenase and pyruvate dehydrogenase.糠醛对乙醇脱氢酶、乙醛脱氢酶和丙酮酸脱氢酶的抑制作用。
Biochem J. 2002 May 1;363(Pt 3):769-76. doi: 10.1042/0264-6021:3630769.

本文引用的文献

1
The occurrence of acetaldehyde in various parts of rat brain after alcohol injection, and its effect on pyruvate oxidation.酒精注射后大鼠脑各部位乙醛的产生及其对丙酮酸氧化的影响。
Exp Cell Res. 1962 Aug;27:367-8. doi: 10.1016/0014-4827(62)90248-3.
2
Evidence for a two-site mechanism for decarboxylation of alpha-keto acids by alpha-carboxylase.α-羧化酶催化α-酮酸脱羧的双位点机制的证据。
J Biol Chem. 1961 Aug;236:2302-8.
3
Effects of aliphatic alcohols and aldehydes on the metabolism of potassium-stimulated rat brain cortex slices.脂肪族醇类和醛类对钾刺激的大鼠大脑皮层切片代谢的影响。
Can J Biochem. 1965 Jul;43(7):1041-51. doi: 10.1139/o65-117.
4
Effects of ethanol on glucose utilization in rat brain.
Proc Soc Exp Biol Med. 1970 Nov;135(2):325-33. doi: 10.3181/00379727-135-35045.
5
An inherited defect affecting the tricarboxylic acid cycle in a patient with congenital lactic acidosis.一名患有先天性乳酸性酸中毒的患者存在影响三羧酸循环的遗传性缺陷。
J Clin Invest. 1972 Jul;51(7):1845-51. doi: 10.1172/JCI106986.
6
Biologic concomitants of alcoholism. 1.酒精中毒的生物学伴随因素。1.
N Engl J Med. 1970 Jul 2;283(1):24-32 contd. doi: 10.1056/NEJM197007022830106.
7
Kinetic properties of the partially purified pyruvate dehydrogenase complex of ox brain.牛脑部分纯化丙酮酸脱氢酶复合体的动力学特性
Biochem J. 1973 Jan;131(1):31-7. doi: 10.1042/bj1310031.
8
A defect in pyruvate decarboxylase in a child with an intermittent movement disorder.一名患有间歇性运动障碍儿童的丙酮酸脱羧酶缺陷。
J Clin Invest. 1970 Mar;49(3):423-32. doi: 10.1172/JCI106251.