Radford D J, Oliver M F
Br Med J. 1973 Aug 25;3(5877):428-30. doi: 10.1136/bmj.3.5877.428.
Between January 1970 and December 1972 22 women aged between 31 and 45 years were admitted to the coronary care unit with acute myocardial infarction and six of these (27%) had been taking oral contraceptives. There were nine women aged 40 or less and five of them (55%) had been on oral contraceptives while three of the other four had been sterilized by tubal interruption.Both these figures of prevalence of oral contraceptive use are significantly greater than estimates for the general population of women of similar age. For those aged 30-44 years, current estimates suggest that it is between 8 and 11%.All the women in this study had risk factors recognized as being associated with the premature development of ischaemic heart disease, and the prevalence of these risk factors was similar in those taking oral contraceptives as in those not doing so. Oral contraceptives probably enhance the chance of developing myocardial infarction in women whose risk is increased for other reasons.
1970年1月至1972年12月期间，22名年龄在31至45岁之间的女性因急性心肌梗死入住冠心病监护病房，其中6名（27%）一直在服用口服避孕药。年龄在40岁及以下的女性有9名，其中5名（55%）一直在服用口服避孕药，另外4名中的3名已通过输卵管结扎绝育。这两个口服避孕药使用 prevalence 的数字均显著高于对年龄相仿的女性普通人群的估计。对于30 - 44岁的女性，目前的估计表明这一比例在8%至11%之间。本研究中的所有女性都有被认为与缺血性心脏病过早发生相关的危险因素，这些危险因素在服用口服避孕药的女性和未服用口服避孕药的女性中 prevalence 相似。口服避孕药可能会增加因其他原因风险增加的女性发生心肌梗死的几率。
