Birgens H S, Hansen O P, Henriksen J H, Wantzin P
Scand J Haematol. 1979 Apr 4;22(4):357-63. doi: 10.1111/j.1600-0609.1979.tb00431.x.
Quantitation of the erythropoiesis with radio-iron (59Fe) was applied to 9 patients with untreated myelomatosis. The method included blocking of the 59Fe reutilization by injection of non-radioactive iron. There was no uniform pattern in the Fe-kinetics values. The Plasma Iron Turnover (PIT) and the Red Blood Cell Iron Turnover (RBCIT) varied from subnormal to values markedly increased above upper normal limit. The calculated average Mean Red Cell Life time (MRCL) of erythrocytes was just below normal range. The mean Marrow Transit Time (MTT) was normal in the patients, despite subnormal venous haematocrit, indicating insufficient stimulation of the bone marrow. The renal function, measured as 51Cr-EDTA clearance, was found positively correlated to the RBCIT (r = 0.78, P less than 0.05). The results suggest that the previously demonstrated relationship between anaemia and renal failure in patients with myelomatosis is caused mainly by an inability of the bone marrow to produce sufficient red blood cells under the stress of anaemia related to the degree of renal impairment.
用放射性铁（59Fe）对9例未经治疗的骨髓瘤患者进行红细胞生成定量研究。该方法包括通过注射非放射性铁来阻断59Fe的再利用。铁动力学值没有统一模式。血浆铁周转率（PIT）和红细胞铁周转率（RBCIT）从低于正常到明显高于正常上限的值不等。计算得出的红细胞平均平均寿命（MRCL）略低于正常范围。尽管静脉血细胞比容低于正常，但患者的平均骨髓 transit 时间（MTT）正常，表明骨髓刺激不足。以51Cr-EDTA清除率衡量的肾功能与RBCIT呈正相关（r = 0.78，P < 0.05）。结果表明，先前在骨髓瘤患者中证明的贫血与肾衰竭之间的关系主要是由于在与肾功能损害程度相关的贫血应激下，骨髓无法产生足够的红细胞。
