Ricketts C, Cavill I, Napier J A, Jacobs A
Br J Haematol. 1977 Jan;35(1):41-7. doi: 10.1111/j.1365-2141.1977.tb00561.x.
The plasma iron clearance half-time and plasma iron turnover have usually been interpreted as measures of total erythroid activity and the red-cell utilization of 59Fe has been equated with effective red-cell production. Erythrocyte iron turnover has sometimes been calculated as the product of plasma iron turnover and percentage utilization. We have assessed these measurements as estimates of erythroid activity by comparing them with total marrow iron turnover and red-cell iron turnover determined by the method of Ricketts et al (1975) in 10 normal subjects and 51 patients with an uncomplicated haematological disorder. The results show that the plasma iron clearance half-time does not reflect erythroid activity and that plasma iron turnover can be particularly misleading in patients with reduced marrow activity. Red-cell utilization and erythrocyte iron turnover give a distorted reflection of effective erythropoiesis except in patients with erythroid hypoplasia. Marrow iron turnover and red-cell iron turnover provide more realistic and generally applicable assessments of the degree and effectiveness of erythroid activity.
血浆铁清除半衰期和血浆铁周转率通常被解释为总红系活性的指标，并且59Fe在红细胞中的利用率已被等同于有效的红细胞生成。红细胞铁周转率有时被计算为血浆铁周转率与利用率百分比的乘积。我们通过将这些测量值与10名正常受试者和51名患有单纯血液系统疾病的患者中采用Ricketts等人（1975年）的方法测定的总骨髓铁周转率和红细胞铁周转率进行比较，来评估这些测量值作为红系活性估计值的情况。结果表明，血浆铁清除半衰期不能反映红系活性，并且血浆铁周转率在骨髓活性降低的患者中可能特别具有误导性。除了红系发育不全的患者外，红细胞利用率和红细胞铁周转率对有效的红细胞生成给出了扭曲的反映。骨髓铁周转率和红细胞铁周转率对红系活性的程度和有效性提供了更现实且普遍适用的评估。
